Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries

Alexey Kamenskiy, Iraklis I Pipinos, Yuris Dzenis, Carol S. Lomneth, Syed A Jaffar Kazmi, Nicholas Y. Phillips, Jason N Mactaggart

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n = 10), popliteal (PA, n = 8) and tibial arteries (TA, n = 3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All specimens exhibited large nonlinear deformations and anisotropy. Under equibiaxial loading, all arteries were stiffer in the circumferential direction than in the longitudinal direction. Anisotropy and longitudinal compliance decreased distally, but circumferential compliance increased, possibly to maintain a homeostatic multiaxial stress state. Constitutive parameters for a four-fiber family invariant-based model were determined for all tissues to calculate in vivo axial pre-stretch that allows the artery to function in the most energy efficient manner while also preventing buckling during extremity flexion. Calculated axial pre-stretch was found to decrease with age, disease severity and more distal arterial location. Histological analysis of the femoropopliteal artery demonstrated a distinct sub-adventitial layer of longitudinal elastin fibers that appeared thicker in healthier arteries. The femoropopliteal artery characteristics and properties determined in this study may assist in devising better diagnostic and treatment modalities for patients with peripheral arterial disease.

Original languageEnglish (US)
Pages (from-to)1301-1313
Number of pages13
JournalActa Biomaterialia
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2014

Fingerprint

Tibial Arteries
Anisotropy
Arteries
Reconstruction (structural)
Elastin
Mechanical properties
Fibers
Buckling
Repair
Tissue
Extremities
Compliance
Adventitia
Peripheral Arterial Disease
Thigh
Direction compound
Ischemia
Therapeutics
Repair Material
1,2-didecanoyl-3-phosphatidic acid

Keywords

  • Biaxial mechanical properties
  • Constitutive modeling
  • Femoropopliteal artery
  • In vivo axial pre-stretch
  • Tibial artery

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries. / Kamenskiy, Alexey; Pipinos, Iraklis I; Dzenis, Yuris; Lomneth, Carol S.; Kazmi, Syed A Jaffar; Phillips, Nicholas Y.; Mactaggart, Jason N.

In: Acta Biomaterialia, Vol. 10, No. 3, 01.03.2014, p. 1301-1313.

Research output: Contribution to journalArticle

@article{df7b1451c0a64469a9dc8572353bee61,
title = "Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries",
abstract = "Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n = 10), popliteal (PA, n = 8) and tibial arteries (TA, n = 3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All specimens exhibited large nonlinear deformations and anisotropy. Under equibiaxial loading, all arteries were stiffer in the circumferential direction than in the longitudinal direction. Anisotropy and longitudinal compliance decreased distally, but circumferential compliance increased, possibly to maintain a homeostatic multiaxial stress state. Constitutive parameters for a four-fiber family invariant-based model were determined for all tissues to calculate in vivo axial pre-stretch that allows the artery to function in the most energy efficient manner while also preventing buckling during extremity flexion. Calculated axial pre-stretch was found to decrease with age, disease severity and more distal arterial location. Histological analysis of the femoropopliteal artery demonstrated a distinct sub-adventitial layer of longitudinal elastin fibers that appeared thicker in healthier arteries. The femoropopliteal artery characteristics and properties determined in this study may assist in devising better diagnostic and treatment modalities for patients with peripheral arterial disease.",
keywords = "Biaxial mechanical properties, Constitutive modeling, Femoropopliteal artery, In vivo axial pre-stretch, Tibial artery",
author = "Alexey Kamenskiy and Pipinos, {Iraklis I} and Yuris Dzenis and Lomneth, {Carol S.} and Kazmi, {Syed A Jaffar} and Phillips, {Nicholas Y.} and Mactaggart, {Jason N}",
year = "2014",
month = "3",
day = "1",
doi = "10.1016/j.actbio.2013.12.027",
language = "English (US)",
volume = "10",
pages = "1301--1313",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries

AU - Kamenskiy, Alexey

AU - Pipinos, Iraklis I

AU - Dzenis, Yuris

AU - Lomneth, Carol S.

AU - Kazmi, Syed A Jaffar

AU - Phillips, Nicholas Y.

AU - Mactaggart, Jason N

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n = 10), popliteal (PA, n = 8) and tibial arteries (TA, n = 3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All specimens exhibited large nonlinear deformations and anisotropy. Under equibiaxial loading, all arteries were stiffer in the circumferential direction than in the longitudinal direction. Anisotropy and longitudinal compliance decreased distally, but circumferential compliance increased, possibly to maintain a homeostatic multiaxial stress state. Constitutive parameters for a four-fiber family invariant-based model were determined for all tissues to calculate in vivo axial pre-stretch that allows the artery to function in the most energy efficient manner while also preventing buckling during extremity flexion. Calculated axial pre-stretch was found to decrease with age, disease severity and more distal arterial location. Histological analysis of the femoropopliteal artery demonstrated a distinct sub-adventitial layer of longitudinal elastin fibers that appeared thicker in healthier arteries. The femoropopliteal artery characteristics and properties determined in this study may assist in devising better diagnostic and treatment modalities for patients with peripheral arterial disease.

AB - Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n = 10), popliteal (PA, n = 8) and tibial arteries (TA, n = 3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All specimens exhibited large nonlinear deformations and anisotropy. Under equibiaxial loading, all arteries were stiffer in the circumferential direction than in the longitudinal direction. Anisotropy and longitudinal compliance decreased distally, but circumferential compliance increased, possibly to maintain a homeostatic multiaxial stress state. Constitutive parameters for a four-fiber family invariant-based model were determined for all tissues to calculate in vivo axial pre-stretch that allows the artery to function in the most energy efficient manner while also preventing buckling during extremity flexion. Calculated axial pre-stretch was found to decrease with age, disease severity and more distal arterial location. Histological analysis of the femoropopliteal artery demonstrated a distinct sub-adventitial layer of longitudinal elastin fibers that appeared thicker in healthier arteries. The femoropopliteal artery characteristics and properties determined in this study may assist in devising better diagnostic and treatment modalities for patients with peripheral arterial disease.

KW - Biaxial mechanical properties

KW - Constitutive modeling

KW - Femoropopliteal artery

KW - In vivo axial pre-stretch

KW - Tibial artery

UR - http://www.scopus.com/inward/record.url?scp=84895067944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895067944&partnerID=8YFLogxK

U2 - 10.1016/j.actbio.2013.12.027

DO - 10.1016/j.actbio.2013.12.027

M3 - Article

C2 - 24370640

AN - SCOPUS:84895067944

VL - 10

SP - 1301

EP - 1313

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 3

ER -