Parvovirus associated fulminant hepatic failure and aplastic anemia treated successfully with liver and bone marrow transplantation. A report of two cases

L. Bathla, W. J. Grant, David F Mercer, Luciano M Vargas, Catherine L Gebhart, Alan Norman Langnas

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4 Citations (Scopus)

Abstract

Aplastic anemia (AA) has been observed in nearly a third of patients undergoing liver transplantation (LT) for non-A-E fulminant hepatic failure (FHF). Few of these patients have been successfully managed with sequential LT and bone marrow transplantation (BMT). No causative agent has been identified for the FHF or AA in these reported cases. At our center, two patients, aged 15 years and 7 years, respectively, underwent sequential living-related LT and living-unrelated BMT. These patients are 10/9 years and 5/4 years post-LT/BMT. Human parvovirus B19 (HPV-B19) was established as the causative agent for FHF in both these patients by polymerase chain reaction. This report presents the first two cases associating HPV-B19 with FHF and AA who underwent sequential LT and BMT with excellent outcomes. The authors describe two cases of parvovirus B19-associated fulminant hepatic failure and aplastic anemia managed with sequential liver and bone marrow transplantation and excellent long-term outcome.

Original languageEnglish (US)
Pages (from-to)2645-2650
Number of pages6
JournalAmerican Journal of Transplantation
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

Parvovirus
Acute Liver Failure
Aplastic Anemia
Bone Marrow Transplantation
Liver Transplantation
Human Parvovirus B19
Liver
Polymerase Chain Reaction

Keywords

  • Bone marrow/hematopoietic stem cell transplantation
  • clinical research/practice
  • fulminant hepatic failure
  • liver transplantation/hepatology
  • liver transplantation: living donor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

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abstract = "Aplastic anemia (AA) has been observed in nearly a third of patients undergoing liver transplantation (LT) for non-A-E fulminant hepatic failure (FHF). Few of these patients have been successfully managed with sequential LT and bone marrow transplantation (BMT). No causative agent has been identified for the FHF or AA in these reported cases. At our center, two patients, aged 15 years and 7 years, respectively, underwent sequential living-related LT and living-unrelated BMT. These patients are 10/9 years and 5/4 years post-LT/BMT. Human parvovirus B19 (HPV-B19) was established as the causative agent for FHF in both these patients by polymerase chain reaction. This report presents the first two cases associating HPV-B19 with FHF and AA who underwent sequential LT and BMT with excellent outcomes. The authors describe two cases of parvovirus B19-associated fulminant hepatic failure and aplastic anemia managed with sequential liver and bone marrow transplantation and excellent long-term outcome.",
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AU - Vargas, Luciano M

AU - Gebhart, Catherine L

AU - Langnas, Alan Norman

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AB - Aplastic anemia (AA) has been observed in nearly a third of patients undergoing liver transplantation (LT) for non-A-E fulminant hepatic failure (FHF). Few of these patients have been successfully managed with sequential LT and bone marrow transplantation (BMT). No causative agent has been identified for the FHF or AA in these reported cases. At our center, two patients, aged 15 years and 7 years, respectively, underwent sequential living-related LT and living-unrelated BMT. These patients are 10/9 years and 5/4 years post-LT/BMT. Human parvovirus B19 (HPV-B19) was established as the causative agent for FHF in both these patients by polymerase chain reaction. This report presents the first two cases associating HPV-B19 with FHF and AA who underwent sequential LT and BMT with excellent outcomes. The authors describe two cases of parvovirus B19-associated fulminant hepatic failure and aplastic anemia managed with sequential liver and bone marrow transplantation and excellent long-term outcome.

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