PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS

T. J. Neale, S. D. Carson, P. G. Tipping, S. R. Holdsworth

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Fibrin deposition is prominent in delayed-type hypersensitivity (DTH) reactions and is initiated by antigen-specific, T-lymphocyte-directed macrophage expression of human tissue factor (HTF). To examine the role of DTH in glomerular fibrin deposition, 10 fibrin-positive and 24 fibrin-negative biopsy specimens from patients with glomerulonephritis (GN) and samples from normal controls were studied with monoclonal antibodies against T cells, macrophages, and HTF. Fibrin-positive sections showed intense glomerular staining for HTF and significantly more T cells and macrophages than fibrin-negative specimens. All the essential elements of DTH reactions can therefore be simultaneously demonstrated within glomeruli from patients with fibrin-related GN. These findings suggest a role for cell mediated immunity in GN.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalThe Lancet
Volume332
Issue number8608
DOIs
StatePublished - Aug 20 1988

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Glomerulonephritis
Fibrin
Cellular Immunity
Delayed Hypersensitivity
Thromboplastin
Macrophages
T-Lymphocytes
Monoclonal Antibodies
Staining and Labeling
Biopsy
Antigens

ASJC Scopus subject areas

  • Medicine(all)

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PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS. / Neale, T. J.; Carson, S. D.; Tipping, P. G.; Holdsworth, S. R.

In: The Lancet, Vol. 332, No. 8608, 20.08.1988, p. 421-424.

Research output: Contribution to journalArticle

Neale, T. J. ; Carson, S. D. ; Tipping, P. G. ; Holdsworth, S. R. / PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS. In: The Lancet. 1988 ; Vol. 332, No. 8608. pp. 421-424.
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