Partial derepression of the isoleucine-valine enzymes during methionine starvation in Salmonella typhimurium

A Angie Rizzino, Michael Mastanduno, Martin Freundlich

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Methionine starvation of methionine auxotrophs in the presence of excess branched-chain amino acids results in a partial derepression of the isoleucine and valine enzymes. Reversed-phase chromatography indicated that isoleucine, valine and leucine tRNA were altered during methionine starvation. In addition, the total tRNA isolated from cells under these conditions was undermethylated. The observed derepression may be caused by the inability of methyl-deficient tRNA's to participate adequately in normal regulatory functions.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume475
Issue number2
DOIs
StatePublished - Mar 18 1977

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Isoleucine
Valine
Salmonella typhimurium
Starvation
Transfer RNA
Methionine
Enzymes
Branched Chain Amino Acids
Reverse-Phase Chromatography
Leucine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Partial derepression of the isoleucine-valine enzymes during methionine starvation in Salmonella typhimurium. / Rizzino, A Angie; Mastanduno, Michael; Freundlich, Martin.

In: BBA Section Nucleic Acids And Protein Synthesis, Vol. 475, No. 2, 18.03.1977, p. 267-275.

Research output: Contribution to journalArticle

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