PARK6, PINK1

B. A. Chase, K. Markopoulou

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

PARK6 mutations affect PTEN induced putative kinase 1 (PINK1), a mitochondrial serine-threonine kinase. Affected individuals show early disease onset, slow progression, and good therapeutic response to levodopa. PINK1 is regulated at multiple levels and functions to maintain mitochondrial integrity under conditions of oxidative stress and proteasomal dysfunction via interactions with TNF receptor associated protein 1 (TRAP1), DJ-1, and HtrA2 (PARK13).

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Pages390-392
Number of pages3
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
DOIs
Publication statusPublished - Jan 1 2010

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Keywords

  • Autophosphorylation
  • DJ-1
  • Dementia
  • Dystonia
  • Early-onset PD
  • HtrA2
  • Mitochondrial protein
  • Mitochondrial stress
  • PARK13
  • PARK6
  • PINK1
  • PTEN-induced putative kinase 1
  • Proteasome
  • Sleep benefit
  • TRAP1

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Chase, B. A., & Markopoulou, K. (2010). PARK6, PINK1. In Encyclopedia of Movement Disorders (pp. 390-392). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374105-9.00502-5