Parenteral galactose therapy in the glucose-intolerant premature infant

John W Sparks, Gordon B. Avery, Anne B. Fletcher, Michael A. Simmons, Walter H. Glinsmann

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Blood galactose concentrations were measured in 55 neonates consuming at least 80 ml/kg/day of lactose-containing formula. The range of galactose concentration immediately after feeding was 0.8 to 4.2 mg/dl, with a mean of 1.5±0.2 mg/dl. Galactose concentration fell rapidly after feeding, and normal values for the population fell with a half-life of 45 minutes. Considering galactose as a potential intravenous nutrient, six glucose-intolerant premature infants were given galactose-containing solutions intravenously using a double-blind randomized crossover protocol. Infants were chosen who had sustained hyperglycemia (150 mg/dl) and glucosuria (2+ Clinitest) requiring glucose infusion at a rate below 7 mg/kg/minute for more than 24 hours. Compared to the control glucose period, intravenous alimentation with a solution containing carbohydrate as 50% glucose and 50% galactose resulted in a 65% increase in total carbohydrate infusion rate, normalization of the blood glucose concentration, and decreased glucosuria. Blood galactose concentration averaged 15 mg/dl, and no clinical or biochemical evidence of galactose toxicity was noted.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalThe Journal of Pediatrics
Volume100
Issue number2
DOIs
StatePublished - Jan 1 1982

Fingerprint

Galactose
Premature Infants
Glucose
Therapeutics
Carbohydrates
Lactose
Hyperglycemia
Half-Life
Blood Glucose
Reference Values
Newborn Infant
Food
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Parenteral galactose therapy in the glucose-intolerant premature infant. / Sparks, John W; Avery, Gordon B.; Fletcher, Anne B.; Simmons, Michael A.; Glinsmann, Walter H.

In: The Journal of Pediatrics, Vol. 100, No. 2, 01.01.1982, p. 255-259.

Research output: Contribution to journalArticle

Sparks, John W ; Avery, Gordon B. ; Fletcher, Anne B. ; Simmons, Michael A. ; Glinsmann, Walter H. / Parenteral galactose therapy in the glucose-intolerant premature infant. In: The Journal of Pediatrics. 1982 ; Vol. 100, No. 2. pp. 255-259.
@article{0f4e4b990b55440ab5f5b0c40cb03b66,
title = "Parenteral galactose therapy in the glucose-intolerant premature infant",
abstract = "Blood galactose concentrations were measured in 55 neonates consuming at least 80 ml/kg/day of lactose-containing formula. The range of galactose concentration immediately after feeding was 0.8 to 4.2 mg/dl, with a mean of 1.5±0.2 mg/dl. Galactose concentration fell rapidly after feeding, and normal values for the population fell with a half-life of 45 minutes. Considering galactose as a potential intravenous nutrient, six glucose-intolerant premature infants were given galactose-containing solutions intravenously using a double-blind randomized crossover protocol. Infants were chosen who had sustained hyperglycemia (150 mg/dl) and glucosuria (2+ Clinitest) requiring glucose infusion at a rate below 7 mg/kg/minute for more than 24 hours. Compared to the control glucose period, intravenous alimentation with a solution containing carbohydrate as 50{\%} glucose and 50{\%} galactose resulted in a 65{\%} increase in total carbohydrate infusion rate, normalization of the blood glucose concentration, and decreased glucosuria. Blood galactose concentration averaged 15 mg/dl, and no clinical or biochemical evidence of galactose toxicity was noted.",
author = "Sparks, {John W} and Avery, {Gordon B.} and Fletcher, {Anne B.} and Simmons, {Michael A.} and Glinsmann, {Walter H.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1016/S0022-3476(82)80651-3",
language = "English (US)",
volume = "100",
pages = "255--259",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Parenteral galactose therapy in the glucose-intolerant premature infant

AU - Sparks, John W

AU - Avery, Gordon B.

AU - Fletcher, Anne B.

AU - Simmons, Michael A.

AU - Glinsmann, Walter H.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Blood galactose concentrations were measured in 55 neonates consuming at least 80 ml/kg/day of lactose-containing formula. The range of galactose concentration immediately after feeding was 0.8 to 4.2 mg/dl, with a mean of 1.5±0.2 mg/dl. Galactose concentration fell rapidly after feeding, and normal values for the population fell with a half-life of 45 minutes. Considering galactose as a potential intravenous nutrient, six glucose-intolerant premature infants were given galactose-containing solutions intravenously using a double-blind randomized crossover protocol. Infants were chosen who had sustained hyperglycemia (150 mg/dl) and glucosuria (2+ Clinitest) requiring glucose infusion at a rate below 7 mg/kg/minute for more than 24 hours. Compared to the control glucose period, intravenous alimentation with a solution containing carbohydrate as 50% glucose and 50% galactose resulted in a 65% increase in total carbohydrate infusion rate, normalization of the blood glucose concentration, and decreased glucosuria. Blood galactose concentration averaged 15 mg/dl, and no clinical or biochemical evidence of galactose toxicity was noted.

AB - Blood galactose concentrations were measured in 55 neonates consuming at least 80 ml/kg/day of lactose-containing formula. The range of galactose concentration immediately after feeding was 0.8 to 4.2 mg/dl, with a mean of 1.5±0.2 mg/dl. Galactose concentration fell rapidly after feeding, and normal values for the population fell with a half-life of 45 minutes. Considering galactose as a potential intravenous nutrient, six glucose-intolerant premature infants were given galactose-containing solutions intravenously using a double-blind randomized crossover protocol. Infants were chosen who had sustained hyperglycemia (150 mg/dl) and glucosuria (2+ Clinitest) requiring glucose infusion at a rate below 7 mg/kg/minute for more than 24 hours. Compared to the control glucose period, intravenous alimentation with a solution containing carbohydrate as 50% glucose and 50% galactose resulted in a 65% increase in total carbohydrate infusion rate, normalization of the blood glucose concentration, and decreased glucosuria. Blood galactose concentration averaged 15 mg/dl, and no clinical or biochemical evidence of galactose toxicity was noted.

UR - http://www.scopus.com/inward/record.url?scp=0020054182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020054182&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(82)80651-3

DO - 10.1016/S0022-3476(82)80651-3

M3 - Article

VL - 100

SP - 255

EP - 259

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 2

ER -