Parasite resource manipulation drives bimodal variation in infection duration

Anieke Van Leeuwen, Sarah A. Budischak, Andrea L. Graham, Clayton E. Cressler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Over a billion people on earth are infected with helminth parasites and show remarkable variation in parasite burden and chronicity. These parasite distributions are captured well by classic statistics, such as the negative binomial distribution. But the within-host processes underlying this variation are not well understood. In this study, we explain variation in macroparasite infection outcomes on the basis of resource flows within hosts. Resource flows realize the interactions between parasites and host immunity and metabolism. When host metabolism is modulated by parasites, we find a positive feedback of parasites on their own resources. While this positive feedback results in parasites improving their resource availability at high burdens, giving rise to chronic infections, it also results in a threshold biomass required for parasites to establish in the host, giving rise to acute infections when biomass fails to clear the threshold. Our finding of chronic and acute outcomes in bistability contrasts with classic theory, yet is congruent with the variation in helminth burdens observed in human and wildlife populations.

Original languageEnglish (US)
Article number20190456
JournalProceedings of the Royal Society B: Biological Sciences
Volume286
Issue number1902
DOIs
StatePublished - May 15 2019

Fingerprint

parasite
Parasites
parasites
duration
resource
Infection
infection
Helminths
Biomass
helminths
Metabolism
Binomial Distribution
metabolism
Host-Parasite Interactions
Feedback
biomass
resource availability
immunity
Immunity
wildlife

Keywords

  • Acute
  • Chronic
  • Immunity
  • Parasite
  • Resource manipulation
  • Within-host

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Parasite resource manipulation drives bimodal variation in infection duration. / Van Leeuwen, Anieke; Budischak, Sarah A.; Graham, Andrea L.; Cressler, Clayton E.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 286, No. 1902, 20190456, 15.05.2019.

Research output: Contribution to journalArticle

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