Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis

Michael F. Sorrell, David A. Burnett, Dean J. Tuma, Anthony J. Barak

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The urinary excretion of D-glucaric acid and the plasma clearance of antipyrine were estimated during the acute phase of viral hepatitis and again during recovery. The plasma clearance of antipyrine was impaired during the acute stage of hepatitis, while the urinary excretion of D-glucaric acid was paradoxically high. Both parameters returned to normal during recovery. These findings suggest that the use of urinary D-glucaric acid excretion as an index of microsomal enzyme induction is unreliable when there is liver injury.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalClinical Pharmacology and Therapeutics
Volume20
Issue number3
DOIs
StatePublished - Sep 1976

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Glucaric Acid
Hepatitis
Antipyrine
Enzyme Induction
Liver
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis. / Sorrell, Michael F.; Burnett, David A.; Tuma, Dean J.; Barak, Anthony J.

In: Clinical Pharmacology and Therapeutics, Vol. 20, No. 3, 09.1976, p. 365-368.

Research output: Contribution to journalArticle

Sorrell, Michael F. ; Burnett, David A. ; Tuma, Dean J. ; Barak, Anthony J. / Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis. In: Clinical Pharmacology and Therapeutics. 1976 ; Vol. 20, No. 3. pp. 365-368.
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