Papillary renal cell-like carcinoma in a retroperitoneal teratoma

Zlatko Marušić, Mario Zovak, Jill M. Hagenkord, Shera Kash, Manika Sapru Koul, Warren G Sanger, Zoran Gatalica, Božo Krušlin, Davor Tomas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a case of somatic type malignancy with papillary renal cell carcinoma differentiation arising in a retroperitoneal mixed germ cell tumor. The patient was a 36-year-old man with a synchronous mediastinal teratoma. The somatic type malignancy in the retroperitoneal tumor was composed of papillary structures covered by atypical epithelial cells with eosinophilic cytoplasm, prominent nucleoli and pseudostratified nuclei. Papillary cores contained numerous aggregates of foamy macrophages, typical of type I papillary renal cell carcinomas. The immunohistochemical profile was consistent with papillary renal cell carcinoma, including positive reactions for cytokeratin 7 and alpha-methyl acyl CoA racemase. There was no somatic type malignancy component in the synchronous mediastinal teratoma. Both the retroperitoneal and the mediastinal tumor showed gains of 12p and chromosome 17 material. There was no c-MET mutation in the somatic type malignancy. To our knowledge, this is the first report of a somatic type malignancy with features of papillary renal cell carcinoma arising in a germ cell tumor. It is important not to confuse such a retroperitoneal tumor with a conventional papillary renal cell carcinoma, because presence of other malignant histologies within the germ cell tumor may warrant different treatment. In such cases, the presence of isochromosome 12p can be helpful to the diagnosis.

Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalPathology International
Volume60
Issue number8
DOIs
StatePublished - Jan 1 2010

Fingerprint

Teratoma
Renal Cell Carcinoma
Germ Cell and Embryonal Neoplasms
Neoplasms
Isochromosomes
Keratin-7
Racemases and Epimerases
Acyl Coenzyme A
Chromosomes, Human, Pair 17
Cell Differentiation
Histology
Cytoplasm
Epithelial Cells
Macrophages
Mutation

Keywords

  • FISH
  • SNP array
  • c-MET
  • papillary renal cell carcinoma
  • teratoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Marušić, Z., Zovak, M., Hagenkord, J. M., Kash, S., Koul, M. S., Sanger, W. G., ... Tomas, D. (2010). Papillary renal cell-like carcinoma in a retroperitoneal teratoma. Pathology International, 60(8), 581-585. https://doi.org/10.1111/j.1440-1827.2010.02559.x

Papillary renal cell-like carcinoma in a retroperitoneal teratoma. / Marušić, Zlatko; Zovak, Mario; Hagenkord, Jill M.; Kash, Shera; Koul, Manika Sapru; Sanger, Warren G; Gatalica, Zoran; Krušlin, Božo; Tomas, Davor.

In: Pathology International, Vol. 60, No. 8, 01.01.2010, p. 581-585.

Research output: Contribution to journalArticle

Marušić, Z, Zovak, M, Hagenkord, JM, Kash, S, Koul, MS, Sanger, WG, Gatalica, Z, Krušlin, B & Tomas, D 2010, 'Papillary renal cell-like carcinoma in a retroperitoneal teratoma', Pathology International, vol. 60, no. 8, pp. 581-585. https://doi.org/10.1111/j.1440-1827.2010.02559.x
Marušić Z, Zovak M, Hagenkord JM, Kash S, Koul MS, Sanger WG et al. Papillary renal cell-like carcinoma in a retroperitoneal teratoma. Pathology International. 2010 Jan 1;60(8):581-585. https://doi.org/10.1111/j.1440-1827.2010.02559.x
Marušić, Zlatko ; Zovak, Mario ; Hagenkord, Jill M. ; Kash, Shera ; Koul, Manika Sapru ; Sanger, Warren G ; Gatalica, Zoran ; Krušlin, Božo ; Tomas, Davor. / Papillary renal cell-like carcinoma in a retroperitoneal teratoma. In: Pathology International. 2010 ; Vol. 60, No. 8. pp. 581-585.
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