Pandemic (H1N1) 2009 virus revisited: An evolutionary retrospective

Mary C. Christman, Ambreen Kedwaii, Jianpeng Xu, Ruben O. Donis, Guoqing Lu

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

The pandemic (H1N1) 2009 virus is unique in many aspects, especially in its genetics and evolution. In this paper, we examine the molecular mechanisms underlying the evolution of this novel virus through a comprehensive bioinformatics analysis, and present results in the context of a review of the literature. The pandemic virus was found to arise from a reassortment of two swine viruses, each of which ultimately arose from interspecies transmission. It experienced fast evolutionary rates and strong selection pressures, diverging into two different clusters at the early pandemic stage. Cluster I became extinct at the end of 2009 whereas Cluster II continued to circulate at much lower rates in 2010. Therefore, on August 10 of 2010 the WHO declared the end of the pandemic. Important mutations associated with host specificity, virulence, and drug resistance were detected in the pandemic virus, indicating effective transmission and increased severity in humans. Much has been learned about the evolutionary dynamics of this pandemic virus; however, it is still impossible to predict when the next pandemic will occur and which virus will be responsible. Improved surveillance at different levels (both national and international) and in different hosts (especially in swine) appears to be crucial for early detection and prevention of future influenza pandemics.

Original languageEnglish (US)
Pages (from-to)803-811
Number of pages9
JournalInfection, Genetics and Evolution
Volume11
Issue number5
DOIs
StatePublished - Jul 1 2011

Fingerprint

H1N1 Subtype Influenza A Virus
Pandemics
pandemic
Influenza A virus
virus
Viruses
viruses
Swine
drug resistance
influenza
bioinformatics
host specificity
swine
Molecular Evolution
virulence
Host Specificity
Computational Biology
Drug Resistance
mutation
Human Influenza

Keywords

  • Evolution
  • Genetic mutation
  • Genome reassortment
  • Influenza
  • Pandemic H1N1
  • Phylodynamics

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Pandemic (H1N1) 2009 virus revisited : An evolutionary retrospective. / Christman, Mary C.; Kedwaii, Ambreen; Xu, Jianpeng; Donis, Ruben O.; Lu, Guoqing.

In: Infection, Genetics and Evolution, Vol. 11, No. 5, 01.07.2011, p. 803-811.

Research output: Contribution to journalReview article

Christman, Mary C. ; Kedwaii, Ambreen ; Xu, Jianpeng ; Donis, Ruben O. ; Lu, Guoqing. / Pandemic (H1N1) 2009 virus revisited : An evolutionary retrospective. In: Infection, Genetics and Evolution. 2011 ; Vol. 11, No. 5. pp. 803-811.
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