Pancreaticoduodenal transplantation in humans

T. E. Starzl, S. Iwatsuki, Byers Wendell Shaw Jr, D. A. Greene, D. H. Van Thiel, M. A. Nalesnik, J. Nusbacher, H. Diliz-Pere, T. R. Hakala

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation. One graft was lost within a few hours from venous thrombosis but with patient survival. The other three are providing normal endocrine function after two and a half, 11 and 12 months. The exocrine pancreatic secretions were drained into the recipient jejunum through enteric anastomoses. Because mucosal slough of the graft and duodenum and jejunum in two patients caused a protein losing enteropathy and necessitated reoperations, we now do the pancreatic transplantation with only a blister of graft duodenum large enough for side-to-side enteroenterostomy. The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalSurgery Gynecology and Obstetrics
Volume159
Issue number3
StatePublished - Oct 25 1984

Fingerprint

Transplantation
Transplants
Jejunum
Duodenum
Pancreas
Protein-Losing Enteropathies
Splenectomy
Blister
Reoperation
Venous Thrombosis
Kidney Transplantation
Spleen
Survival

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Cite this

Starzl, T. E., Iwatsuki, S., Shaw Jr, B. W., Greene, D. A., Van Thiel, D. H., Nalesnik, M. A., ... Hakala, T. R. (1984). Pancreaticoduodenal transplantation in humans. Surgery Gynecology and Obstetrics, 159(3), 265-272.

Pancreaticoduodenal transplantation in humans. / Starzl, T. E.; Iwatsuki, S.; Shaw Jr, Byers Wendell; Greene, D. A.; Van Thiel, D. H.; Nalesnik, M. A.; Nusbacher, J.; Diliz-Pere, H.; Hakala, T. R.

In: Surgery Gynecology and Obstetrics, Vol. 159, No. 3, 25.10.1984, p. 265-272.

Research output: Contribution to journalArticle

Starzl, TE, Iwatsuki, S, Shaw Jr, BW, Greene, DA, Van Thiel, DH, Nalesnik, MA, Nusbacher, J, Diliz-Pere, H & Hakala, TR 1984, 'Pancreaticoduodenal transplantation in humans', Surgery Gynecology and Obstetrics, vol. 159, no. 3, pp. 265-272.
Starzl TE, Iwatsuki S, Shaw Jr BW, Greene DA, Van Thiel DH, Nalesnik MA et al. Pancreaticoduodenal transplantation in humans. Surgery Gynecology and Obstetrics. 1984 Oct 25;159(3):265-272.
Starzl, T. E. ; Iwatsuki, S. ; Shaw Jr, Byers Wendell ; Greene, D. A. ; Van Thiel, D. H. ; Nalesnik, M. A. ; Nusbacher, J. ; Diliz-Pere, H. ; Hakala, T. R. / Pancreaticoduodenal transplantation in humans. In: Surgery Gynecology and Obstetrics. 1984 ; Vol. 159, No. 3. pp. 265-272.
@article{435106a7683345ef9189a3ee92ffdc5e,
title = "Pancreaticoduodenal transplantation in humans",
abstract = "Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation. One graft was lost within a few hours from venous thrombosis but with patient survival. The other three are providing normal endocrine function after two and a half, 11 and 12 months. The exocrine pancreatic secretions were drained into the recipient jejunum through enteric anastomoses. Because mucosal slough of the graft and duodenum and jejunum in two patients caused a protein losing enteropathy and necessitated reoperations, we now do the pancreatic transplantation with only a blister of graft duodenum large enough for side-to-side enteroenterostomy. The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications.",
author = "Starzl, {T. E.} and S. Iwatsuki and {Shaw Jr}, {Byers Wendell} and Greene, {D. A.} and {Van Thiel}, {D. H.} and Nalesnik, {M. A.} and J. Nusbacher and H. Diliz-Pere and Hakala, {T. R.}",
year = "1984",
month = "10",
day = "25",
language = "English (US)",
volume = "159",
pages = "265--272",
journal = "Journal of the American College of Surgeons",
issn = "1072-7515",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Pancreaticoduodenal transplantation in humans

AU - Starzl, T. E.

AU - Iwatsuki, S.

AU - Shaw Jr, Byers Wendell

AU - Greene, D. A.

AU - Van Thiel, D. H.

AU - Nalesnik, M. A.

AU - Nusbacher, J.

AU - Diliz-Pere, H.

AU - Hakala, T. R.

PY - 1984/10/25

Y1 - 1984/10/25

N2 - Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation. One graft was lost within a few hours from venous thrombosis but with patient survival. The other three are providing normal endocrine function after two and a half, 11 and 12 months. The exocrine pancreatic secretions were drained into the recipient jejunum through enteric anastomoses. Because mucosal slough of the graft and duodenum and jejunum in two patients caused a protein losing enteropathy and necessitated reoperations, we now do the pancreatic transplantation with only a blister of graft duodenum large enough for side-to-side enteroenterostomy. The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications.

AB - Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation. One graft was lost within a few hours from venous thrombosis but with patient survival. The other three are providing normal endocrine function after two and a half, 11 and 12 months. The exocrine pancreatic secretions were drained into the recipient jejunum through enteric anastomoses. Because mucosal slough of the graft and duodenum and jejunum in two patients caused a protein losing enteropathy and necessitated reoperations, we now do the pancreatic transplantation with only a blister of graft duodenum large enough for side-to-side enteroenterostomy. The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications.

UR - http://www.scopus.com/inward/record.url?scp=0021260828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021260828&partnerID=8YFLogxK

M3 - Article

VL - 159

SP - 265

EP - 272

JO - Journal of the American College of Surgeons

JF - Journal of the American College of Surgeons

SN - 1072-7515

IS - 3

ER -