Pancreatic polypeptide cell proliferation in the pancreas and duodenum coexisting in a patient with pancreatic adenocarcinoma treated with a GLP-1 analog

Geoffrey A Talmon, J. David Wren, Christophe L. Nguyen, Parviz M. Pour

Research output: Contribution to journalArticle

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Abstract

A partial pancreaticogastrodudenectomy was performed on a 66-year old man with type 2 diabetes mellitus because of an invasive,moderately differentiated adenocarcinoma in the head of the pancreas. In the adjacent grossly normal tissue of the uncinate process, there was a massive proliferation of pancreatic polypeptide (PP) cells confined to this region and showed invasive pattern. Strikingly, in the heaped area of his duodenum, there was a strikingly large number of PP, glucagon, a few insulin cells in a mini-islet-like patterns composed of glucagon and insulin cells. Among the etiological factors, the possible long-lasting effects of the GLP-1 analog, with which the patient was treated, are discussed. This is the first report in the literature of both the coexistence of a pancreatic adenocarcinoma and invasive PPoma and the occurrence of PP and insulin cells in human duodenal mucosa.

Original languageEnglish (US)
Pages (from-to)820-824
Number of pages5
JournalPancreas
Volume46
Issue number6
DOIs
Publication statusPublished - Jan 1 2017

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Keywords

  • Cancer
  • Duodenal lesion
  • Hyperplasia
  • Pancreas
  • Pancreatic hormones
  • Pancreatic polypeptide

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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