Pancreas transplantation

Indications and consequences

Research output: Contribution to journalReview article

106 Citations (Scopus)

Abstract

Pancreas transplantation continues to evolve as a strategy in the management of diabetes mellitus. The first combined pancreas-kidney transplant was reported in 1967, but pancreas transplant now represents a number of procedures, each with different indications, risks, benefits, and outcomes. This review will summarize these procedures, including their risks and outcomes in comparison to kidney transplantation alone, and how or if they affect the consequences of diabetes: hyperglycemia, hypoglycemia, and microvascular and macrovascular complications. In addition, the new risks introduced by immunosuppression will be reviewed, including infections, cancer, osteoporosis, reproductive function, and the impact of immunosuppression medications on blood pressure, lipids, and glucose tolerance. It is imperative that an endocrinologist remain involved in the care of the pancreas transplant recipient, even when glucose is normal, because of the myriad of issues encountered post transplant, including ongoing management of diabetic complications, prevention of bone loss, and screening for failure of the pancreas graft with reinstitution of treatment when indicated. Although long-term patient and graft survival have improved greatly after pancreas transplant, a multidisciplinary team is needed to maximize long-term quality, as well as quantity, of life for the pancreas transplant recipient.

Original languageEnglish (US)
Pages (from-to)919-946
Number of pages28
JournalEndocrine Reviews
Volume25
Issue number6
DOIs
StatePublished - Dec 1 2004

Fingerprint

Pancreas Transplantation
Pancreas
Transplants
Immunosuppression
Graft Survival
Diabetes Complications
Hypoglycemia
Hyperglycemia
Kidney Transplantation
Osteoporosis
Blood Glucose
Diabetes Mellitus
Blood Pressure
Kidney
Lipids
Bone and Bones
Glucose
Infection
Neoplasms

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Pancreas transplantation : Indications and consequences. / Larsen, Jennifer Lynn.

In: Endocrine Reviews, Vol. 25, No. 6, 01.12.2004, p. 919-946.

Research output: Contribution to journalReview article

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