P66Shc- A longevity redox protein in human prostate cancer progression and metastasis: P66Shc in cancer progression and metastasis

Mythilypriya Rajendran, Paul G Thomes, Li Zhang, Suresh Veeramani, Ming-Fong Lin

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

p66Shc, a 66 kDa proto-oncogene Src homologous-collagen homologue (Shc) adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and recently identified as a sensor to oxidative stress-induced apoptosis and as a longevity protein in mammals. The expression of p66Shc is decreased in mice and increased in human fibroblasts upon aging and in aging-related diseases, including prostate cancer. p66Shc protein level correlates with the proliferation of several carcinoma cells and can be regulated by steroid hormones. Recent advances point that p66Shc protein plays a role in mediating cross-talk between steroid hormones and redox signals by serving as a common convergence point in signaling pathways on cell proliferation and apoptosis. This article first reviews the unique function of p66Shc protein in regulating oxidative stress-induced apoptosis. Subsequently, we discuss its novel role in androgen-regulated prostate cancer cell proliferation and metastasis and the mechanism by which it mediates androgen action via the redox signaling pathway. The data together indicate that p66Shc might be a useful biomarker for the prognosis of prostate cancer and serve as an effective target for its cancer treatment.

Original languageEnglish (US)
Pages (from-to)207-222
Number of pages16
JournalCancer and Metastasis Reviews
Volume29
Issue number1
DOIs
Publication statusPublished - Mar 1 2010

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Keywords

  • Apoptosis
  • Cell proliferation
  • Metastasis
  • P66Shc
  • Prostate cancer
  • Redox

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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