P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2)

Takeshi Iwamura, Thomas C. Caffrey, Norio Kitamura, Hideo Yamanari, Toshiaki Setoguchi, Michael A Hollingsworth

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The human pancreatic tumor cell line SUIT-2 was derived from a metastatic lesion in the liver of a patient with pancreatic adenocarcinoma. SUIT-2 and clonal cell lines derived from it show spontaneous metastasis to lung and regional lymph nodes from s.c. nude mouse xenografts and were found to express P-selectin mRNA and protein. Surface expression of P-selectin protein was increased by exposure of the pancreatic tumor cells to thrombin, oxygen radicals, and trypsin, suggesting that common cellular mechanisms for regulating P-selectin surface expression exist among platelets, endothelial cells, and these pancreatic tumor cells. The finding that P-selectin is expressed by metastatic pancreatic tumor cells demonstrates that the range of cell types that express these adhesion molecules is broader than believed previously.

Original languageEnglish (US)
Pages (from-to)1206-1212
Number of pages7
JournalCancer Research
Volume57
Issue number6
StatePublished - Apr 9 1997

Fingerprint

P-Selectin
Tumor Cell Line
Neoplasms
Cell Adhesion Molecules
Heterografts
Nude Mice
Thrombin
Trypsin
Reactive Oxygen Species
Proteins
Adenocarcinoma
Blood Platelets
Endothelial Cells
Lymph Nodes
Neoplasm Metastasis
Cell Line
Lung
Messenger RNA
Liver

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Iwamura, T., Caffrey, T. C., Kitamura, N., Yamanari, H., Setoguchi, T., & Hollingsworth, M. A. (1997). P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2). Cancer Research, 57(6), 1206-1212.

P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2). / Iwamura, Takeshi; Caffrey, Thomas C.; Kitamura, Norio; Yamanari, Hideo; Setoguchi, Toshiaki; Hollingsworth, Michael A.

In: Cancer Research, Vol. 57, No. 6, 09.04.1997, p. 1206-1212.

Research output: Contribution to journalArticle

Iwamura, T, Caffrey, TC, Kitamura, N, Yamanari, H, Setoguchi, T & Hollingsworth, MA 1997, 'P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2)', Cancer Research, vol. 57, no. 6, pp. 1206-1212.
Iwamura T, Caffrey TC, Kitamura N, Yamanari H, Setoguchi T, Hollingsworth MA. P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2). Cancer Research. 1997 Apr 9;57(6):1206-1212.
Iwamura, Takeshi ; Caffrey, Thomas C. ; Kitamura, Norio ; Yamanari, Hideo ; Setoguchi, Toshiaki ; Hollingsworth, Michael A. / P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2). In: Cancer Research. 1997 ; Vol. 57, No. 6. pp. 1206-1212.
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