P-31 spectroscopy study of response of superficial human tumors to therapy

Gregory S. Karczmar, Dieter J. Meyerhoff, Michael D. Boska, Bruno Hubesch, Julie Poole, Gerald B. Matson, Frank Valone, Michael W. Weiner

Research output: Contribution to journalArticle

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Abstract

Studies were performed to characterize phosphorus-31 magnetic resonance (MR) spectra obtained from 10 superficial human tumors outside the brain and to determine whether P-31 MR spectroscopy could allow detection of a response to therapy before a change in tumor size was measured. The ratio of phosphomonoester to adenosine triphosphate peak intensities (PME/ ATP) was unusually large in all tumors studied. The average PME/ ATP in lymphomas (1.8 ± 0.5) was greater than in nonlymphoma cancers (1.1 ± 0.15). The average PME/ ATP for all tumors studied (1.4 ± 0.5) was much greater than that of underlying skeletal muscle (0.23 ± .09). Eight of the tumors were studied before and after therapy. Responders were distinguished from nonresponders on the basis of changes in tumor size. PME/ATP decreased during therapy in three lymphomas that responded to therapy. In an adenocarcinoma and Ewing sarcoma that did not respond to therapy, PME/ATP increased. PME/ ATP remained constant in two squamous cell carcinomas that responded to therapy and decreased in one squamous cell carcinoma that decreased in size by 40% but was classified as a nonresponder. Changes in PME/ATP did not always parallel changes in tumor size during therapy. In two patients, a decrease in PME/ATP preceded a decrease in tumor size. In four patients, PME/ ATP increased transiently during periods when tumor size remained constant.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalRadiology
Volume179
Issue number1
DOIs
StatePublished - Apr 1991

Fingerprint

Spectrum Analysis
Adenosine Triphosphate
Neoplasms
Therapeutics
Squamous Cell Carcinoma
Lymphoma
Magnetic Resonance Spectroscopy
Ewing's Sarcoma
Brain Neoplasms
Phosphorus
Skeletal Muscle
Adenocarcinoma

Keywords

  • Head and neck neoplasms
  • Lymphoma, MR studies, 99.1214
  • Magnetic resonance (MR), phosphorus studies
  • Magnetic resonance (MR), spectroscopy
  • Magnetic resonance (MR), tissue characterization
  • Magnetic resonance (MR), treatment planning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Karczmar, G. S., Meyerhoff, D. J., Boska, M. D., Hubesch, B., Poole, J., Matson, G. B., ... Weiner, M. W. (1991). P-31 spectroscopy study of response of superficial human tumors to therapy. Radiology, 179(1), 149-153. https://doi.org/10.1148/radiology.179.1.2006266

P-31 spectroscopy study of response of superficial human tumors to therapy. / Karczmar, Gregory S.; Meyerhoff, Dieter J.; Boska, Michael D.; Hubesch, Bruno; Poole, Julie; Matson, Gerald B.; Valone, Frank; Weiner, Michael W.

In: Radiology, Vol. 179, No. 1, 04.1991, p. 149-153.

Research output: Contribution to journalArticle

Karczmar, GS, Meyerhoff, DJ, Boska, MD, Hubesch, B, Poole, J, Matson, GB, Valone, F & Weiner, MW 1991, 'P-31 spectroscopy study of response of superficial human tumors to therapy', Radiology, vol. 179, no. 1, pp. 149-153. https://doi.org/10.1148/radiology.179.1.2006266
Karczmar GS, Meyerhoff DJ, Boska MD, Hubesch B, Poole J, Matson GB et al. P-31 spectroscopy study of response of superficial human tumors to therapy. Radiology. 1991 Apr;179(1):149-153. https://doi.org/10.1148/radiology.179.1.2006266
Karczmar, Gregory S. ; Meyerhoff, Dieter J. ; Boska, Michael D. ; Hubesch, Bruno ; Poole, Julie ; Matson, Gerald B. ; Valone, Frank ; Weiner, Michael W. / P-31 spectroscopy study of response of superficial human tumors to therapy. In: Radiology. 1991 ; Vol. 179, No. 1. pp. 149-153.
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