Oxytocin improves specific recognition of positive facial expressions

Abigail A. Marsh, Henry H. Yu, Daniel S. Pine, R. J.R. Blair

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Background Oxytocin is a neuropeptide that is associated with increased trust. Perceptions of trustworthiness are associated with detection of positive facial affect, which suggests that oxytocin may enhance the recognition of positive facial affect. The present study tests this hypothesis. Methods A double-blind, between-groups design was used, with 50 volunteers randomly assigned to receive intranasally administered oxytocin or placebo. Thirty-five minutes following the administration of oxytocin or placebo, participants identified anger, disgust, fear, happiness, sadness, and surprise expressions that were morphed with neutral faces such that they varied from 10% to 100% intensity. Results Oxytocin significantly and specifically improved the recognition of happy facial expressions; no significant differences in recognition of other expression were found. The improvement was not associated with gender, response biases, or changes in mood, and it was most pronounced for subtle expressions. Conclusions Acute oxytocin administration enhances healthy adults' ability to accurately identify positive emotional facial expressions. These findings reinforce oxytocin's role in facilitating affiliative interactions and have implications for the treatment of conditions that are marked by social affiliation deficits.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalPsychopharmacology
Volume209
Issue number3
DOIs
StatePublished - Apr 1 2010

Fingerprint

Facial Expression
Oxytocin
Placebos
Sexism
Happiness
Aptitude
Social Conditions
Anger
Neuropeptides
Double-Blind Method
Fear
Volunteers

Keywords

  • Affinity
  • Emotion facial
  • Neuropeptide
  • Oxytoci

ASJC Scopus subject areas

  • Pharmacology

Cite this

Oxytocin improves specific recognition of positive facial expressions. / Marsh, Abigail A.; Yu, Henry H.; Pine, Daniel S.; Blair, R. J.R.

In: Psychopharmacology, Vol. 209, No. 3, 01.04.2010, p. 225-232.

Research output: Contribution to journalArticle

Marsh, Abigail A. ; Yu, Henry H. ; Pine, Daniel S. ; Blair, R. J.R. / Oxytocin improves specific recognition of positive facial expressions. In: Psychopharmacology. 2010 ; Vol. 209, No. 3. pp. 225-232.
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