Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers

Jon Cavanaugh, Aaryn C. Mustoe, Jack H. Taylor, Jeffrey A. French

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Behavioral strategies that facilitate the maintenance of social bonds are critical for the preservation of high-quality social relationships. Central oxytocin (OT) activity modulates the behavioral features of socially monogamous relationships in a number of mammalian species (including marmoset monkeys), and plays a vital role in the behavioral maintenance of long-term social relationships. Two distinct variants of OT have been identified in some New World primates (including marmosets; Lee et al., 2011). The marmoset variant of the oxytocin ligand (Pro8-OT) is structurally distinct from the consensus mammalian variant of the oxytocin ligand (Leu8-OT), due to a proline substitution at the 8th amino-acid position. The goal of the present study was to determine if treating marmosets with Pro8-OT, relative to treatments with Leu8-OT, control saline, or an OT antagonist, had modulatory effects on the behavioral maintenance of long-term social relationships in marmosets. Treatment with the Pro8 variant, but not the Leu8 variant, of OT facilitated fidelity with a long-term partner by reducing time spent in close proximity with an opposite-sex stranger. However, this facilitative effect of Pro8-OT on proximity behavior manifested itself differently in male and female marmosets, such that females preferred to interact socially with their partner rather than a stranger when treated with Pro8-OT, while males spent less time in close proximity with both their partner and a stranger when treated with Pro8-OT. Furthermore, treatment with Pro8-OT, but not Leu8-OT, significantly delayed the expression of sexual solicitation behavior toward an opposite-sex stranger in both male and female marmosets, but had no effect on sociosexual behavior directed toward a long-term partner. These results suggest that the OT system is highly involved in reducing fidelity-threatening behaviors in well-established marmoset pairs, and that the effects were only produced by species-specific OT ligands.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalPsychoneuroendocrinology
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Fidelity
  • Oxytocin
  • Pair-bond relationships
  • Partner-preference
  • Pro-OT
  • Social behavior

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers. / Cavanaugh, Jon; Mustoe, Aaryn C.; Taylor, Jack H.; French, Jeffrey A.

In: Psychoneuroendocrinology, Vol. 49, No. 1, 01.01.2014, p. 1-10.

Research output: Contribution to journalArticle

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