Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration

Annadurai Anandhan, Pablo Hernandez-Franco, Rodrigo Franco-Cruz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

NF-κB is a multifunctional redox sensitive transcription factor. In neurodegenerative disorders such as Alzheimer's, Huntington's, Parkinson's disease and amyotrophic lateral sclerosis (ALS), inducible NF-κB activation is observed in glial cells (astrocytes and microglia) as an inflammatory response that regulates the expression of cytokines, chemokines and adhesion molecules as well as the generation of reactive oxygen (ROS) and nitrogen species (RNS). As such, NF-κB activation is thought to contribute to neuronal loss. However, there is strong evidence demonstrating that in neurons, NF-κB protects against cell death progression by regulation of anti-apoptotic genes. Understanding the molecular pathways involved in NF-κB activation during neurodegeneration and its downstream signaling mediating pro-survival, pro-death and inflammatory responses will provide novel targets for therapeutic intervention. In this chapter we revise the role of NF-κB in neurodegeneration, its role in oxidative stress and antioxidant defense in the brain, and its regulation by redox homeostasis and oxidative stress.

Original languageEnglish (US)
Title of host publicationOxidative Stress
Subtitle of host publicationDiagnostics, Prevention, and Therapy Volume 2
EditorsSilvana Andreescu, Maria Hepel
PublisherAmerican Chemical Society
Pages53-90
Number of pages38
ISBN (Electronic)9780841231009
DOIs
StatePublished - Jan 1 2015

Publication series

NameACS Symposium Series
Volume1200
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

Fingerprint

Oxidative stress
Chemical activation
Transcription factors
Cell death
Antioxidants
Chemokines
Neurons
Brain
Transcription Factors
Nitrogen
Adhesion
Genes
Cytokines
Oxygen
Molecules
Oxidation-Reduction

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Anandhan, A., Hernandez-Franco, P., & Franco-Cruz, R. (2015). Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration. In S. Andreescu, & M. Hepel (Eds.), Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2 (pp. 53-90). (ACS Symposium Series; Vol. 1200). American Chemical Society. https://doi.org/10.1021/bk-2015-1200.ch003

Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration. / Anandhan, Annadurai; Hernandez-Franco, Pablo; Franco-Cruz, Rodrigo.

Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. ed. / Silvana Andreescu; Maria Hepel. American Chemical Society, 2015. p. 53-90 (ACS Symposium Series; Vol. 1200).

Research output: Chapter in Book/Report/Conference proceedingChapter

Anandhan, A, Hernandez-Franco, P & Franco-Cruz, R 2015, Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration. in S Andreescu & M Hepel (eds), Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. ACS Symposium Series, vol. 1200, American Chemical Society, pp. 53-90. https://doi.org/10.1021/bk-2015-1200.ch003
Anandhan A, Hernandez-Franco P, Franco-Cruz R. Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration. In Andreescu S, Hepel M, editors, Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. American Chemical Society. 2015. p. 53-90. (ACS Symposium Series). https://doi.org/10.1021/bk-2015-1200.ch003
Anandhan, Annadurai ; Hernandez-Franco, Pablo ; Franco-Cruz, Rodrigo. / Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration. Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. editor / Silvana Andreescu ; Maria Hepel. American Chemical Society, 2015. pp. 53-90 (ACS Symposium Series).
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