Oxidative stress, DNA methylation and carcinogenesis

Rodrigo Franco, Onard Schoneveld, Alexandros G. Georgakilas, Mihalis I. Panayiotidis

Research output: Contribution to journalShort survey

384 Citations (Scopus)

Abstract

Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis.

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalCancer Letters
Volume266
Issue number1
DOIs
StatePublished - Jul 18 2008

Fingerprint

DNA Methylation
Epigenomics
Carcinogenesis
Oxidative Stress
Genetic Epigenesis
Gene Expression Regulation
Tumor Biomarkers
Tumor Suppressor Genes
Oncogenes
Genes

Keywords

  • Cancer
  • DNA methylation
  • Epigenetics
  • Free radicals
  • Gene expression
  • Oxidative DNA damage
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Franco, R., Schoneveld, O., Georgakilas, A. G., & Panayiotidis, M. I. (2008). Oxidative stress, DNA methylation and carcinogenesis. Cancer Letters, 266(1), 6-11. https://doi.org/10.1016/j.canlet.2008.02.026

Oxidative stress, DNA methylation and carcinogenesis. / Franco, Rodrigo; Schoneveld, Onard; Georgakilas, Alexandros G.; Panayiotidis, Mihalis I.

In: Cancer Letters, Vol. 266, No. 1, 18.07.2008, p. 6-11.

Research output: Contribution to journalShort survey

Franco, R, Schoneveld, O, Georgakilas, AG & Panayiotidis, MI 2008, 'Oxidative stress, DNA methylation and carcinogenesis', Cancer Letters, vol. 266, no. 1, pp. 6-11. https://doi.org/10.1016/j.canlet.2008.02.026
Franco, Rodrigo ; Schoneveld, Onard ; Georgakilas, Alexandros G. ; Panayiotidis, Mihalis I. / Oxidative stress, DNA methylation and carcinogenesis. In: Cancer Letters. 2008 ; Vol. 266, No. 1. pp. 6-11.
@article{74d03a08b7414d9cb58ecd33d22f7c03,
title = "Oxidative stress, DNA methylation and carcinogenesis",
abstract = "Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis.",
keywords = "Cancer, DNA methylation, Epigenetics, Free radicals, Gene expression, Oxidative DNA damage, Oxidative stress, Reactive oxygen species",
author = "Rodrigo Franco and Onard Schoneveld and Georgakilas, {Alexandros G.} and Panayiotidis, {Mihalis I.}",
year = "2008",
month = "7",
day = "18",
doi = "10.1016/j.canlet.2008.02.026",
language = "English (US)",
volume = "266",
pages = "6--11",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Oxidative stress, DNA methylation and carcinogenesis

AU - Franco, Rodrigo

AU - Schoneveld, Onard

AU - Georgakilas, Alexandros G.

AU - Panayiotidis, Mihalis I.

PY - 2008/7/18

Y1 - 2008/7/18

N2 - Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis.

AB - Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression phases of the carcinogenic process. Genes in each of these phases acquire alterations in their transcriptional activity that are associated either with hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes). Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such we can hypothesize of potential mode(s) of action by which oxidative stress modulates epigenetic regulation of gene expression. This is of outmost importance given that various components of the epigenetic pathway and primarily aberrant DNA methylation patterns are used as potential biomarkers for cancer diagnosis and prognosis.

KW - Cancer

KW - DNA methylation

KW - Epigenetics

KW - Free radicals

KW - Gene expression

KW - Oxidative DNA damage

KW - Oxidative stress

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=44449148691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44449148691&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.02.026

DO - 10.1016/j.canlet.2008.02.026

M3 - Short survey

C2 - 18372104

AN - SCOPUS:44449148691

VL - 266

SP - 6

EP - 11

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -