Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking

X. Shang, Y. Chen, N. Wang, W. Niu, J. Guo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.

Original languageEnglish (US)
Pages (from-to)4172-4175
Number of pages4
JournalChemical Communications
Volume54
Issue number33
DOIs
StatePublished - Jan 1 2018

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Crosslinking
Proteins
Oxidation
Nucleophiles
Molecules

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking. / Shang, X.; Chen, Y.; Wang, N.; Niu, W.; Guo, J.

In: Chemical Communications, Vol. 54, No. 33, 01.01.2018, p. 4172-4175.

Research output: Contribution to journalArticle

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