Oxalate secretion in the rat proximal tubule

T. F. Knight, Steven Claude Sansom, H. O. Senekjian, E. J. Weinman

Research output: Contribution to journalArticle

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Abstract

Simultaneous capillary and luminal microperfusion studies in the proximal convoluted tubule of the rat were performed to examine the transepithelial secretory flux of [14C]oxalate. Increases in the concentration of oxalate in the capillary solution from 0.096 to 4.3 mM resulted in progressively higher rates of oxalate secretion into the lumen. Further increases in the capillary concentration of oxalate indicated a tendency toward a plateau. The inclusion of para-chloromercuribenzoate, sodium cyanide, indanyloxyacetic acid, furosemide, or para-aminohippurate in the capillary solution significantly lowered the secretory flux of oxalate. The addition of probenecid in a concentration of 10-4 M inhibited oxalate secretion when the oxalate concentration in the capillary solution ranged between 1.1 and 4.3 mM, but did not affect oxalate secretion at higher capillary concentrations of oxalate. These results indicate that oxalate secretion in the rat proximal tubule is an active carrier-mediated process. When considered in conjunction with prior studies, the present investigations suggest the possibility that more than one oxalate secretory system exists in the rat proximal tubule.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume9
Issue number4
StatePublished - Jan 1 1981

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Oxalates
p-Chloromercuribenzoic Acid
Sodium Cyanide
Probenecid
Furosemide

ASJC Scopus subject areas

  • Physiology

Cite this

Oxalate secretion in the rat proximal tubule. / Knight, T. F.; Sansom, Steven Claude; Senekjian, H. O.; Weinman, E. J.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 9, No. 4, 01.01.1981, p. 295-298.

Research output: Contribution to journalArticle

Knight, T. F. ; Sansom, Steven Claude ; Senekjian, H. O. ; Weinman, E. J. / Oxalate secretion in the rat proximal tubule. In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1981 ; Vol. 9, No. 4. pp. 295-298.
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