Oxacycle synthesis via intramolecular reaction of carbanions and peroxides

Rachel Willand-Charnley, Benjamin W. Puffer, Patrick H. Dussault

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.

Original languageEnglish (US)
Pages (from-to)5821-5823
Number of pages3
JournalJournal of the American Chemical Society
Volume136
Issue number16
DOIs
StatePublished - Apr 23 2014

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Cyclic Ethers
Deprotonation
Peroxides
Ethers
Ion exchange
Metals

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Oxacycle synthesis via intramolecular reaction of carbanions and peroxides. / Willand-Charnley, Rachel; Puffer, Benjamin W.; Dussault, Patrick H.

In: Journal of the American Chemical Society, Vol. 136, No. 16, 23.04.2014, p. 5821-5823.

Research output: Contribution to journalArticle

Willand-Charnley, Rachel ; Puffer, Benjamin W. ; Dussault, Patrick H. / Oxacycle synthesis via intramolecular reaction of carbanions and peroxides. In: Journal of the American Chemical Society. 2014 ; Vol. 136, No. 16. pp. 5821-5823.
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