Overview of toll-like receptors in the CNS

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. Over the past eight years, the number of manuscripts describing TLR expression and function in the central nervous system (CNS) has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled Toll-Like Receptors: Roles in Infection and Neuropathology. The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in noninfectious neurodegenerative diseases and the challenges faced by these models in identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCurrent Topics in Microbiology and Immunology
Volume336
Issue number1
DOIs
StatePublished - 2009

Fingerprint

Toll-Like Receptors
Central Nervous System
Neurodegenerative Diseases
Communicable Diseases
Manuscripts
Microbiology
Allergy and Immunology
Innate Immunity
Diptera
Drosophila
Ligands
Wounds and Injuries
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Overview of toll-like receptors in the CNS. / Kielian, Tammy L.

In: Current Topics in Microbiology and Immunology, Vol. 336, No. 1, 2009, p. 1-14.

Research output: Contribution to journalArticle

@article{7bcfd1850c6548448e9f821f59ef63f5,
title = "Overview of toll-like receptors in the CNS",
abstract = "Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. Over the past eight years, the number of manuscripts describing TLR expression and function in the central nervous system (CNS) has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled Toll-Like Receptors: Roles in Infection and Neuropathology. The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in noninfectious neurodegenerative diseases and the challenges faced by these models in identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes.",
author = "Kielian, {Tammy L}",
year = "2009",
doi = "10.1007/978-3-642-00549-7-1",
language = "English (US)",
volume = "336",
pages = "1--14",
journal = "Current Topics in Microbiology and Immunology",
issn = "0070-217X",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Overview of toll-like receptors in the CNS

AU - Kielian, Tammy L

PY - 2009

Y1 - 2009

N2 - Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. Over the past eight years, the number of manuscripts describing TLR expression and function in the central nervous system (CNS) has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled Toll-Like Receptors: Roles in Infection and Neuropathology. The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in noninfectious neurodegenerative diseases and the challenges faced by these models in identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes.

AB - Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. Over the past eight years, the number of manuscripts describing TLR expression and function in the central nervous system (CNS) has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled Toll-Like Receptors: Roles in Infection and Neuropathology. The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in noninfectious neurodegenerative diseases and the challenges faced by these models in identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes.

UR - http://www.scopus.com/inward/record.url?scp=77649234691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649234691&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-00549-7-1

DO - 10.1007/978-3-642-00549-7-1

M3 - Article

VL - 336

SP - 1

EP - 14

JO - Current Topics in Microbiology and Immunology

JF - Current Topics in Microbiology and Immunology

SN - 0070-217X

IS - 1

ER -