Overview of the lymphoid neoplasms

Nikolai Podoltsev, Jill Lacy, Julie Marie Vose

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lymphomas comprise a diverse array of neoplasms that arise from lymphoid cells. It is now widely accepted that distinct subtypes of lymphoma arise from and correlate with subsets of normal lymphocytes at discrete points in lymphocyte development or maturation. Molecular mechanisms of lymphoma pathogenesis also correlate with lymphoid cell physiology deregulated by identifiable genetic events. Better understanding of the pathogenesis of lymphomas has led to advances in their classification and treatment outcomes. The WHO classification of lymphoid malignancies was updated in 2008 and is based on histologic features, immunophenotype, cytogenetics, and epidemiologic/etiologic factors. The major clinical groupings include non-Hodgkin lymphomas (NHL), Hodgkin lymphomas (HL), and plasma cell neoplasms. Given the intimate relationship between the basic concepts of immunobiology and lymphomagenesis, the first portion of this chapter is devoted to an overview of the fundamentals of the Immune System. The second portion of this chapter discusses the clinical aspects of lymphoma and includes brief descriptions of the common subtypes of lymphoma.

Original languageEnglish (US)
Title of host publicationLymphoma and Leukemia of the Nervous System
PublisherSpringer New York
Pages3-39
Number of pages37
ISBN (Electronic)9781441976680
ISBN (Print)9781441976673
DOIs
StatePublished - Jan 1 2012

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Lymphoma
Neoplasms
Lymphocytes
Plasma Cell Neoplasms
Epidemiologic Factors
Cell Physiological Phenomena
Lymphocyte Subsets
Hodgkin Disease
Cytogenetics
Non-Hodgkin's Lymphoma
Immune System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Podoltsev, N., Lacy, J., & Vose, J. M. (2012). Overview of the lymphoid neoplasms. In Lymphoma and Leukemia of the Nervous System (pp. 3-39). Springer New York. https://doi.org/10.1007/9781441976680_1

Overview of the lymphoid neoplasms. / Podoltsev, Nikolai; Lacy, Jill; Vose, Julie Marie.

Lymphoma and Leukemia of the Nervous System. Springer New York, 2012. p. 3-39.

Research output: Chapter in Book/Report/Conference proceedingChapter

Podoltsev, N, Lacy, J & Vose, JM 2012, Overview of the lymphoid neoplasms. in Lymphoma and Leukemia of the Nervous System. Springer New York, pp. 3-39. https://doi.org/10.1007/9781441976680_1
Podoltsev N, Lacy J, Vose JM. Overview of the lymphoid neoplasms. In Lymphoma and Leukemia of the Nervous System. Springer New York. 2012. p. 3-39 https://doi.org/10.1007/9781441976680_1
Podoltsev, Nikolai ; Lacy, Jill ; Vose, Julie Marie. / Overview of the lymphoid neoplasms. Lymphoma and Leukemia of the Nervous System. Springer New York, 2012. pp. 3-39
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