Abstract

The mononuclear phagocyte (MP; monocyte, macrophages, dendritic cells and microglia) is part of innate immunity that functions by nonspecific surveillance and clearing response through phagocytic and intracellular killing activities. MPs included are present within the reticular connective tissues and accumulate in lymph nodes, spleen, liver and as histiocytes, tissue macrophages, Kupffer cells and microglia. It is estimated that there are at any time six billion MP/L of blood. MPs are divided into non-professional and professional categories based on function. Phagocytosis is a key function that phagocytes possess to survey their environment, ingest and process material. This chapter expands on the mechanisms, benefits, and uses of the mononuclear phagocyte.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Pages141-153
Number of pages13
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Antigen presentation
  • Complement receptors
  • Experimental allergic encephalomyelitis
  • Lectin
  • Mononuclear phagocyte
  • Phagocytosis
  • Progenitor cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Banoub, M. G., & Gendelman, H. E. (2016). Overview of mononuclear phagocytes. In Neuroimmune Pharmacology (pp. 141-153). Springer International Publishing. https://doi.org/10.1007/978-3-319-44022-4_11