Overexpression of the Fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis

Jianxiang Wang, Tetsuya Otsuki, Hagop Youssoufian, Jerome Lo Ten Foe, Sonnie Kim, Marcel Devetten, Jianmei Yu, Youlin Li, Daniel Dunn, Johnson M. Liu

Research output: Contribution to journalArticle

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Abstract

Fanconi anemia is a rare, inherited disorder characterized by bone marrow failure, congenital malformations, and cancer susceptibility. The group C Fanconi anemia gene, FAC, identified by expression cloning methods, encodes a protein of unknown function that may be involved in the response to apoptotic stimuli. Hematopoietic progenitor cells from Fac knock-out mice are hypersensitive to IFN-γ, a molecule that can induce apoptosis through up- regulation of the Fas death receptor. In this study, we used FAC- overexpressing transgenic mice to examine the relationship between FAC and Fas-triggered cell death. Hematopoietic progenitors from FAC-transgenic mice were up to 10-fold less sensitive to the cytolytic effect of Fas-ligation. Our experiments implicate FAC in the regulation of apoptosis mediated by the Fas death receptor.

Original languageEnglish (US)
Pages (from-to)3538-3541
Number of pages4
JournalCancer Research
Volume58
Issue number16
StatePublished - Aug 15 1998

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CD95 Antigens
Fanconi Anemia
Death Domain Receptors
Transgenic Mice
Apoptosis
Hematopoietic Stem Cells
Knockout Mice
Genes
Ligation
Organism Cloning
Cell Death
Up-Regulation
Bone Marrow
Neoplasms
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wang, J., Otsuki, T., Youssoufian, H., Lo Ten Foe, J., Kim, S., Devetten, M., ... Liu, J. M. (1998). Overexpression of the Fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis. Cancer Research, 58(16), 3538-3541.

Overexpression of the Fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis. / Wang, Jianxiang; Otsuki, Tetsuya; Youssoufian, Hagop; Lo Ten Foe, Jerome; Kim, Sonnie; Devetten, Marcel; Yu, Jianmei; Li, Youlin; Dunn, Daniel; Liu, Johnson M.

In: Cancer Research, Vol. 58, No. 16, 15.08.1998, p. 3538-3541.

Research output: Contribution to journalArticle

Wang, J, Otsuki, T, Youssoufian, H, Lo Ten Foe, J, Kim, S, Devetten, M, Yu, J, Li, Y, Dunn, D & Liu, JM 1998, 'Overexpression of the Fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis', Cancer Research, vol. 58, no. 16, pp. 3538-3541.
Wang, Jianxiang ; Otsuki, Tetsuya ; Youssoufian, Hagop ; Lo Ten Foe, Jerome ; Kim, Sonnie ; Devetten, Marcel ; Yu, Jianmei ; Li, Youlin ; Dunn, Daniel ; Liu, Johnson M. / Overexpression of the Fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis. In: Cancer Research. 1998 ; Vol. 58, No. 16. pp. 3538-3541.
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AU - Kim, Sonnie

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