Ovarian Follicle Biology and the Basis for Gonadotoxicity

Marilia Henriques Cordeiro, So Youn Kim, Teresa K. Woodruff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Normal ovarian function requires tight control of germ cell meiosis and the quantitative activation or loss of ovarian follicles from the primordial follicle pool over the reproductive lifespan. The mechanisms controlling the activation of specific subsets of primordial follicles during this lengthy time are complex, involving coordination of what we now understand to be multiple molecular cues. In this chapter we review ovarian follicle development from initial formation in the embryo to activation, growth and endocrine regulation during the normal reproductive lifespan. We discuss how the unique features of primordial follicle biology relate to their vulnerability to chemotherapy and radiation treatment, emphasizing the importance of preserving the ovarian reserve to ensure normal ovarian function and the endocrine health of the individual.

Original languageEnglish (US)
Title of host publicationCancer Treatment and the Ovary
Subtitle of host publicationClinical and Laboratory Analysis of Ovarian Toxicity
PublisherElsevier Inc.
Pages3-20
Number of pages18
ISBN (Electronic)9780128016015
ISBN (Print)9780128015919
DOIs
StatePublished - Sep 1 2015

Fingerprint

Ovarian Follicle
Coordination Complexes
Meiosis
Germ Cells
Cues
Embryonic Structures
Radiation
Drug Therapy
Health
Growth
Therapeutics
Ovarian Reserve

Keywords

  • Endocrine system
  • Follicle
  • Follicle activation
  • Follicle death
  • Folliculogenesis
  • Ovarian hormones
  • Ovarian reserve
  • Ovary

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cordeiro, M. H., Kim, S. Y., & Woodruff, T. K. (2015). Ovarian Follicle Biology and the Basis for Gonadotoxicity. In Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity (pp. 3-20). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801591-9.00001-1

Ovarian Follicle Biology and the Basis for Gonadotoxicity. / Cordeiro, Marilia Henriques; Kim, So Youn; Woodruff, Teresa K.

Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity. Elsevier Inc., 2015. p. 3-20.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cordeiro, MH, Kim, SY & Woodruff, TK 2015, Ovarian Follicle Biology and the Basis for Gonadotoxicity. in Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity. Elsevier Inc., pp. 3-20. https://doi.org/10.1016/B978-0-12-801591-9.00001-1
Cordeiro MH, Kim SY, Woodruff TK. Ovarian Follicle Biology and the Basis for Gonadotoxicity. In Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity. Elsevier Inc. 2015. p. 3-20 https://doi.org/10.1016/B978-0-12-801591-9.00001-1
Cordeiro, Marilia Henriques ; Kim, So Youn ; Woodruff, Teresa K. / Ovarian Follicle Biology and the Basis for Gonadotoxicity. Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity. Elsevier Inc., 2015. pp. 3-20
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