Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997.

Y. J. Hutin, R. J. Williams, P. Malfait, R. Pebody, V. N. Loparev, S. L. Ropp, M. Rodriguez, J. C. Knight, F. K. Tshioko, A. S. Khan, M. V. Szczeniowski, J. J. Esposito

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Human monkeypox is a zoonotic smallpox-like disease caused by an orthopoxvirus of interhuman transmissibility too low to sustain spread in susceptible populations. In February 1997, 88 cases of febrile pustular rash were identified for the previous 12 months in 12 villages of the Katako-Kombe Health Zone, Democratic Republic of Congo (attack rate = 22 per 1,000; case-fatality rate = 3.7%). Seven were active cases confirmed by virus isolation. Orthopoxvirus- neutralizing antibodies were detected in 54% of 72 patients who provided serum and 25% of 59 wild-caught animals, mainly squirrels. Hemagglutination-inhibition assays and Western blotting detected antibodies in 68% and 73% of patients, respectively. Vaccinia vaccination, which protects against monkeypox, ceased by 1983 after global smallpox eradication, leading to an increase in the proportion of susceptible people.

Original languageEnglish (US)
Pages (from-to)434-438
Number of pages5
JournalEmerging infectious diseases
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2001

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Monkeypox
Orthopoxvirus
Democratic Republic of the Congo
Smallpox
Disease Outbreaks
Vaccinia
Sciuridae
Wild Animals
Zoonoses
Hemagglutination
Exanthema
Neutralizing Antibodies
Vaccination
Fever
Western Blotting
Viruses
Mortality
Antibodies
Health
Serum

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Hutin, Y. J., Williams, R. J., Malfait, P., Pebody, R., Loparev, V. N., Ropp, S. L., ... Esposito, J. J. (2001). Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerging infectious diseases, 7(3), 434-438. https://doi.org/10.3201/eid0703.017311

Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. / Hutin, Y. J.; Williams, R. J.; Malfait, P.; Pebody, R.; Loparev, V. N.; Ropp, S. L.; Rodriguez, M.; Knight, J. C.; Tshioko, F. K.; Khan, A. S.; Szczeniowski, M. V.; Esposito, J. J.

In: Emerging infectious diseases, Vol. 7, No. 3, 01.01.2001, p. 434-438.

Research output: Contribution to journalArticle

Hutin, YJ, Williams, RJ, Malfait, P, Pebody, R, Loparev, VN, Ropp, SL, Rodriguez, M, Knight, JC, Tshioko, FK, Khan, AS, Szczeniowski, MV & Esposito, JJ 2001, 'Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997.', Emerging infectious diseases, vol. 7, no. 3, pp. 434-438. https://doi.org/10.3201/eid0703.017311
Hutin YJ, Williams RJ, Malfait P, Pebody R, Loparev VN, Ropp SL et al. Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerging infectious diseases. 2001 Jan 1;7(3):434-438. https://doi.org/10.3201/eid0703.017311
Hutin, Y. J. ; Williams, R. J. ; Malfait, P. ; Pebody, R. ; Loparev, V. N. ; Ropp, S. L. ; Rodriguez, M. ; Knight, J. C. ; Tshioko, F. K. ; Khan, A. S. ; Szczeniowski, M. V. ; Esposito, J. J. / Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. In: Emerging infectious diseases. 2001 ; Vol. 7, No. 3. pp. 434-438.
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