Abstract
Human monkeypox is a zoonotic smallpox-like disease caused by an orthopoxvirus of interhuman transmissibility too low to sustain spread in susceptible populations. In February 1997, 88 cases of febrile pustular rash were identified for the previous 12 months in 12 villages of the Katako-Kombe Health Zone, Democratic Republic of Congo (attack rate = 22 per 1,000; case-fatality rate = 3.7%). Seven were active cases confirmed by virus isolation. Orthopoxvirus- neutralizing antibodies were detected in 54% of 72 patients who provided serum and 25% of 59 wild-caught animals, mainly squirrels. Hemagglutination-inhibition assays and Western blotting detected antibodies in 68% and 73% of patients, respectively. Vaccinia vaccination, which protects against monkeypox, ceased by 1983 after global smallpox eradication, leading to an increase in the proportion of susceptible people.
Original language | English (US) |
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Pages (from-to) | 434-438 |
Number of pages | 5 |
Journal | Emerging infectious diseases |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1 2001 |
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ASJC Scopus subject areas
- Epidemiology
- Microbiology (medical)
- Infectious Diseases
Cite this
Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. / Hutin, Y. J.; Williams, R. J.; Malfait, P.; Pebody, R.; Loparev, V. N.; Ropp, S. L.; Rodriguez, M.; Knight, J. C.; Tshioko, F. K.; Khan, A. S.; Szczeniowski, M. V.; Esposito, J. J.
In: Emerging infectious diseases, Vol. 7, No. 3, 01.01.2001, p. 434-438.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997.
AU - Hutin, Y. J.
AU - Williams, R. J.
AU - Malfait, P.
AU - Pebody, R.
AU - Loparev, V. N.
AU - Ropp, S. L.
AU - Rodriguez, M.
AU - Knight, J. C.
AU - Tshioko, F. K.
AU - Khan, A. S.
AU - Szczeniowski, M. V.
AU - Esposito, J. J.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Human monkeypox is a zoonotic smallpox-like disease caused by an orthopoxvirus of interhuman transmissibility too low to sustain spread in susceptible populations. In February 1997, 88 cases of febrile pustular rash were identified for the previous 12 months in 12 villages of the Katako-Kombe Health Zone, Democratic Republic of Congo (attack rate = 22 per 1,000; case-fatality rate = 3.7%). Seven were active cases confirmed by virus isolation. Orthopoxvirus- neutralizing antibodies were detected in 54% of 72 patients who provided serum and 25% of 59 wild-caught animals, mainly squirrels. Hemagglutination-inhibition assays and Western blotting detected antibodies in 68% and 73% of patients, respectively. Vaccinia vaccination, which protects against monkeypox, ceased by 1983 after global smallpox eradication, leading to an increase in the proportion of susceptible people.
AB - Human monkeypox is a zoonotic smallpox-like disease caused by an orthopoxvirus of interhuman transmissibility too low to sustain spread in susceptible populations. In February 1997, 88 cases of febrile pustular rash were identified for the previous 12 months in 12 villages of the Katako-Kombe Health Zone, Democratic Republic of Congo (attack rate = 22 per 1,000; case-fatality rate = 3.7%). Seven were active cases confirmed by virus isolation. Orthopoxvirus- neutralizing antibodies were detected in 54% of 72 patients who provided serum and 25% of 59 wild-caught animals, mainly squirrels. Hemagglutination-inhibition assays and Western blotting detected antibodies in 68% and 73% of patients, respectively. Vaccinia vaccination, which protects against monkeypox, ceased by 1983 after global smallpox eradication, leading to an increase in the proportion of susceptible people.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035349885&partnerID=8YFLogxK
U2 - 10.3201/eid0703.017311
DO - 10.3201/eid0703.017311
M3 - Article
C2 - 11384521
AN - SCOPUS:0035349885
VL - 7
SP - 434
EP - 438
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 3
ER -