Osteopontin prevents monocyte recirculation and apoptosis

Tricia H. Burdo, Malcolm R. Wood, Howard S. Fox

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Cells of the monocyte/macrophage lineage have been shown to be the principal targets for productive HIV-1 replication within the CNS. In addition, HIV-1-associated dementia (HAD) has been shown to correlate with macrophage abundance in the brain. Although increased entry of monocytes into the brain is thought to initiate this process, mechanisms that prevent macrophage egress from the brain and means that prevent macrophage death may also contribute to cell accumulation. We hypothesized that osteopontin (OPN) was involved in the accumulation of macrophages in the brain in neuroAIDS. Using in vitro model systems, we have demonstrated the role of OPN in two distinct aspects of macrophage accumulation: prevention from recirculation and protection from apoptosis. In these unique mechanisms, OPN would aid in macrophage survival and accumulation in the brain, the pathological substrate of HAD.

Original languageEnglish (US)
Pages (from-to)1504-1511
Number of pages8
JournalJournal of Leukocyte Biology
Volume81
Issue number6
DOIs
Publication statusPublished - Jun 1 2007

    Fingerprint

Keywords

  • AIDS
  • HIV
  • Macrophage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this