Oscillatory MEG motor activity reflects therapy-related plasticity in stroke patients

Tony W Wilson, Anne Fleischer, Darlene Archer, Satoru Hayasaka, Lumy Sawaki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. A goal of stroke rehabilitation is to harness the capacity of the brain to reorganize following neurological damage and enable restoration of function. Objective. To understand how neural oscillatory motor responses change following a therapeutic intervention and to illuminate whether these neurophysiological alterations correlate with improvements on behavioral measurements. Methods. Magnetoencephalography (MEG) was used to evaluate plasticity in motor networks following 2 weeks of intensive task-oriented therapy, which was paired with sham or peripheral nerve stimulation (PNS). Patients completed unilateral finger tapping before and 3 weeks after therapy as whole-head MEG data were acquired. MEG data were imaged using beamforming, and the resulting event-related synchronizations and desynchronizations (ERSs/ERDs) were subjected to region-of-interest (ROI) analyses. For each ROI, the authors compared the baseline and postintervention MEG response amplitude, volume, and peak location for premovement βERD, movement-onset γERS, and postmovement βERS. Results. Following therapy, all patients showed reduced postmovement βERS response amplitudes in bilateral precentral gyri and reduced γERS amplitudes in the precentral gyrus of the affected hemisphere. This latter response also distinguished treatment groups, as the posttherapy γ reduction was greater in patients who received PNS. Finally, both β and γ response amplitudes were significantly correlated with improvement on several behavioral indices of motor function. Discussion. These case-series data indicate that oscillatory MEG responses may be useful in gauging plasticity in motor cortices following therapy in stroke patients.

Original languageEnglish (US)
Pages (from-to)188-193
Number of pages6
JournalNeurorehabilitation and Neural Repair
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Magnetoencephalography
Motor Activity
Stroke
Frontal Lobe
Peripheral Nerves
Therapeutics
Motor Cortex
Fingers
Head
Brain

Keywords

  • Constraint-induced movement therapy
  • Event-related synchronization
  • Magnetoencephalography
  • Peripheral nerve stimulation
  • Plasticity
  • Stroke rehabilitation

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

Cite this

Oscillatory MEG motor activity reflects therapy-related plasticity in stroke patients. / Wilson, Tony W; Fleischer, Anne; Archer, Darlene; Hayasaka, Satoru; Sawaki, Lumy.

In: Neurorehabilitation and Neural Repair, Vol. 25, No. 2, 01.02.2011, p. 188-193.

Research output: Contribution to journalArticle

Wilson, Tony W ; Fleischer, Anne ; Archer, Darlene ; Hayasaka, Satoru ; Sawaki, Lumy. / Oscillatory MEG motor activity reflects therapy-related plasticity in stroke patients. In: Neurorehabilitation and Neural Repair. 2011 ; Vol. 25, No. 2. pp. 188-193.
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