Orthotopic liver transplantation in children. Two-year experience with 47 patients

J. C. Gartner, B. J. Zitelli, J. J. Malatack, B. W. Shaw, S. Iwatsuki, T. E. Starzl

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

During a 24-month period (May 1981 to May 1983), 47 pediatric patients (ranging in age from 7 months to 18 years) underwent orthotopic liver transplantation using cyclosporine and prednisone. Major indications were biliary atresia/hypoplasia, and metabolic liver disease. Thirty-two of 138 patients evaluated for the procedure died prior to transplantation. Thirty patients are alive from 6 to 29 months later including 7/15 patients who required retransplantation. Twenty-one of 32 patients are alive at 1 year following initial transplantation. All 30 survivors are clinically well and living at home; only one has an abnormal bilirubin level. Serious, life-threatening medical and surgical complications were common during the early months following transplantation. With one exception, deaths and major rejection episodes occurred early (before 120 days). All survivors are relieved of the stigmata of chronic liver disease, and many have demonstrated catch-up growth. Liver transplantation is an effective treatment for end-stage pediatric liver disease.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalPediatrics
Volume74
Issue number1
StatePublished - Aug 23 1984

Fingerprint

Liver Transplantation
Transplantation
Survivors
Liver Diseases
Pediatrics
Biliary Atresia
Christianity
End Stage Liver Disease
Metabolic Diseases
Prednisone
Bilirubin
Cyclosporine
Chronic Disease
Growth
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gartner, J. C., Zitelli, B. J., Malatack, J. J., Shaw, B. W., Iwatsuki, S., & Starzl, T. E. (1984). Orthotopic liver transplantation in children. Two-year experience with 47 patients. Pediatrics, 74(1), 140-145.

Orthotopic liver transplantation in children. Two-year experience with 47 patients. / Gartner, J. C.; Zitelli, B. J.; Malatack, J. J.; Shaw, B. W.; Iwatsuki, S.; Starzl, T. E.

In: Pediatrics, Vol. 74, No. 1, 23.08.1984, p. 140-145.

Research output: Contribution to journalArticle

Gartner, JC, Zitelli, BJ, Malatack, JJ, Shaw, BW, Iwatsuki, S & Starzl, TE 1984, 'Orthotopic liver transplantation in children. Two-year experience with 47 patients', Pediatrics, vol. 74, no. 1, pp. 140-145.
Gartner JC, Zitelli BJ, Malatack JJ, Shaw BW, Iwatsuki S, Starzl TE. Orthotopic liver transplantation in children. Two-year experience with 47 patients. Pediatrics. 1984 Aug 23;74(1):140-145.
Gartner, J. C. ; Zitelli, B. J. ; Malatack, J. J. ; Shaw, B. W. ; Iwatsuki, S. ; Starzl, T. E. / Orthotopic liver transplantation in children. Two-year experience with 47 patients. In: Pediatrics. 1984 ; Vol. 74, No. 1. pp. 140-145.
@article{bd53b9329e2e43b5933f167be0142628,
title = "Orthotopic liver transplantation in children. Two-year experience with 47 patients",
abstract = "During a 24-month period (May 1981 to May 1983), 47 pediatric patients (ranging in age from 7 months to 18 years) underwent orthotopic liver transplantation using cyclosporine and prednisone. Major indications were biliary atresia/hypoplasia, and metabolic liver disease. Thirty-two of 138 patients evaluated for the procedure died prior to transplantation. Thirty patients are alive from 6 to 29 months later including 7/15 patients who required retransplantation. Twenty-one of 32 patients are alive at 1 year following initial transplantation. All 30 survivors are clinically well and living at home; only one has an abnormal bilirubin level. Serious, life-threatening medical and surgical complications were common during the early months following transplantation. With one exception, deaths and major rejection episodes occurred early (before 120 days). All survivors are relieved of the stigmata of chronic liver disease, and many have demonstrated catch-up growth. Liver transplantation is an effective treatment for end-stage pediatric liver disease.",
author = "Gartner, {J. C.} and Zitelli, {B. J.} and Malatack, {J. J.} and Shaw, {B. W.} and S. Iwatsuki and Starzl, {T. E.}",
year = "1984",
month = "8",
day = "23",
language = "English (US)",
volume = "74",
pages = "140--145",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1",

}

TY - JOUR

T1 - Orthotopic liver transplantation in children. Two-year experience with 47 patients

AU - Gartner, J. C.

AU - Zitelli, B. J.

AU - Malatack, J. J.

AU - Shaw, B. W.

AU - Iwatsuki, S.

AU - Starzl, T. E.

PY - 1984/8/23

Y1 - 1984/8/23

N2 - During a 24-month period (May 1981 to May 1983), 47 pediatric patients (ranging in age from 7 months to 18 years) underwent orthotopic liver transplantation using cyclosporine and prednisone. Major indications were biliary atresia/hypoplasia, and metabolic liver disease. Thirty-two of 138 patients evaluated for the procedure died prior to transplantation. Thirty patients are alive from 6 to 29 months later including 7/15 patients who required retransplantation. Twenty-one of 32 patients are alive at 1 year following initial transplantation. All 30 survivors are clinically well and living at home; only one has an abnormal bilirubin level. Serious, life-threatening medical and surgical complications were common during the early months following transplantation. With one exception, deaths and major rejection episodes occurred early (before 120 days). All survivors are relieved of the stigmata of chronic liver disease, and many have demonstrated catch-up growth. Liver transplantation is an effective treatment for end-stage pediatric liver disease.

AB - During a 24-month period (May 1981 to May 1983), 47 pediatric patients (ranging in age from 7 months to 18 years) underwent orthotopic liver transplantation using cyclosporine and prednisone. Major indications were biliary atresia/hypoplasia, and metabolic liver disease. Thirty-two of 138 patients evaluated for the procedure died prior to transplantation. Thirty patients are alive from 6 to 29 months later including 7/15 patients who required retransplantation. Twenty-one of 32 patients are alive at 1 year following initial transplantation. All 30 survivors are clinically well and living at home; only one has an abnormal bilirubin level. Serious, life-threatening medical and surgical complications were common during the early months following transplantation. With one exception, deaths and major rejection episodes occurred early (before 120 days). All survivors are relieved of the stigmata of chronic liver disease, and many have demonstrated catch-up growth. Liver transplantation is an effective treatment for end-stage pediatric liver disease.

UR - http://www.scopus.com/inward/record.url?scp=0021215272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021215272&partnerID=8YFLogxK

M3 - Article

C2 - 6377219

AN - SCOPUS:0021215272

VL - 74

SP - 140

EP - 145

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -