Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation

David F. Rhodes, William M. Lee, John R. Wingard, Michael D. Pavy, George W. Santos, Byers W. Shaw, R. Patrick Wood, Michael Floyd Sorrell, Rodney Smith Markin

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-induced cirrhosis and recurrent variceal hemorrhage. She underwent successful orthotopic liver transplant. Her postoperative course was uncomplicated, with no evidence of rejection or recurrence of graft-vs.-host disease. As bone marrow transplantation is more widely used and survival improves, the number of patients with graft-vs.-host disease or venoocclusive disease resulting in cirrhosis is likely to increase. Hepatic transplantation should be considered for bone marrow transplant patients who develop end-stage liver disease.

Original languageEnglish (US)
Pages (from-to)536-538
Number of pages3
JournalGastroenterology
Volume99
Issue number2
DOIs
Publication statusPublished - Aug 1990

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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