Abstract

Six transplantations of the liver were performed over a period of six years in five adult patients with Type I diabetes mellitus (DM). The diabetic group included two males and three females with a mean age of 36 years and a mean duration of DM of 20 years. Primary diseases of the liver included two instances of primary biliary cirrhosis, two instances of sclerosing cholangitis and one instance of autoimmune chronic hepatitis. Three patients also received a simultaneous whole organ pancreatic transplant. All patients were managed with cyclosporine and prednisone immunosuppression with selective OKT3 induction. Patient and hepatic allograft survival rates were 80 and 67 percent, respectively, after a mean follow-up period of 4.7 years. One of the three pancreatic grafts was successful and resulted in euglycemia for two years. Three patients have subsequently undergone successful renal transplantation at one, two and one-half, and six and one-half years after hepatic transplantation. Although transplantation of the liver can be performed safely in carefully selected patients with Type I DM, these patients are still at risk for the development of progressive nephropathy. Renal transplantation is an acceptable therapeutic alternative when this occurs.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalJournal of the American College of Surgeons
Volume178
Issue number4
StatePublished - Jan 1 1994

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Type 1 Diabetes Mellitus
Liver Transplantation
Kidney Transplantation
Transplants
Muromonab-CD3
Autoimmune Hepatitis
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Prednisone
Immunosuppression
Cyclosporine
Allografts
Liver Diseases
Diabetes Mellitus
Survival Rate
Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Orthotopic hepatic transplantation in patients with type I diabetes mellitus. / Trail, E. G.; Stratta, R. J.; Larsen, Jennifer Lynn; Langnas, Alan Norman; Donovan, J. P.; Sorrell, Michael Floyd; Zetterman, Rowen K; Taylor, R. J.; Shaw, B. W.

In: Journal of the American College of Surgeons, Vol. 178, No. 4, 01.01.1994, p. 337-342.

Research output: Contribution to journalArticle

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