Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity

Siming Ma, Sang Goo Lee, Eun Bae Kim, Thomas J. Park, Andrei Seluanov, Vera Gorbunova, Rochelle Buffenstein, Javier Seravalli, Vadim N. Gladyshev

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Trace elements are essential to all mammals, but their distribution and utilization across species and organs remains unclear. Here, we examined 18 elements in the brain, heart, kidney, and liver of 26 mammalian species and report the elemental composition of these organs, the patterns of utilization across the species, and their correlation with body mass and longevity. Across the organs, we observed distinct distribution patterns for abundant elements, transition metals, and toxic elements. Some elements showed lineage-specific patterns, including reduced selenium utilization in African mole rats, and positive correlation between the number of selenocysteine residues in selenoprotein P and the selenium levels in liver and kidney across mammals. Body mass was linked positively to zinc levels, whereas species lifespan correlated positively with cadmium and negatively with selenium. This study provides insights into the variation of mammalian ionome by organ physiology, lineage specialization, body mass, and longevity.

Original languageEnglish (US)
Pages (from-to)1319-1326
Number of pages8
JournalCell Reports
Volume13
Issue number7
DOIs
StatePublished - Nov 17 2015

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Selenium
Mammals
Chemical elements
Liver
Transition Elements
Selenoprotein P
Mole Rats
Selenocysteine
Kidney
Poisons
Physiology
Trace Elements
Cadmium
Transition metals
Zinc
Rats
Brain
Metals
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ma, S., Lee, S. G., Kim, E. B., Park, T. J., Seluanov, A., Gorbunova, V., ... Gladyshev, V. N. (2015). Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Reports, 13(7), 1319-1326. https://doi.org/10.1016/j.celrep.2015.10.014

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. / Ma, Siming; Lee, Sang Goo; Kim, Eun Bae; Park, Thomas J.; Seluanov, Andrei; Gorbunova, Vera; Buffenstein, Rochelle; Seravalli, Javier; Gladyshev, Vadim N.

In: Cell Reports, Vol. 13, No. 7, 17.11.2015, p. 1319-1326.

Research output: Contribution to journalArticle

Ma, S, Lee, SG, Kim, EB, Park, TJ, Seluanov, A, Gorbunova, V, Buffenstein, R, Seravalli, J & Gladyshev, VN 2015, 'Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity', Cell Reports, vol. 13, no. 7, pp. 1319-1326. https://doi.org/10.1016/j.celrep.2015.10.014
Ma, Siming ; Lee, Sang Goo ; Kim, Eun Bae ; Park, Thomas J. ; Seluanov, Andrei ; Gorbunova, Vera ; Buffenstein, Rochelle ; Seravalli, Javier ; Gladyshev, Vadim N. / Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. In: Cell Reports. 2015 ; Vol. 13, No. 7. pp. 1319-1326.
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