Organic radical contrast agents for magnetic resonance imaging

Andrzej Rajca, Ying Wang, Michael Boska, Joseph T. Paletta, Arnon Olankitwanit, Michael A. Swanson, Deborah G. Mitchell, Sandra S. Eaton, Gareth R. Eaton, Suchada Rajca

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular 1H water relaxivity (r1) is ca. 5 mM-1 s-1. The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.

Original languageEnglish (US)
Pages (from-to)15724-15727
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number38
DOIs
StatePublished - Sep 26 2012

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Magnetic resonance
Contrast Media
Magnetic Resonance Imaging
Imaging techniques
Dendrimers
Ethylene Glycol
Scaffolds
Polyethylene glycols
Free Radicals
Metals
Injections
Water

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Rajca, A., Wang, Y., Boska, M., Paletta, J. T., Olankitwanit, A., Swanson, M. A., ... Rajca, S. (2012). Organic radical contrast agents for magnetic resonance imaging. Journal of the American Chemical Society, 134(38), 15724-15727. https://doi.org/10.1021/ja3079829

Organic radical contrast agents for magnetic resonance imaging. / Rajca, Andrzej; Wang, Ying; Boska, Michael; Paletta, Joseph T.; Olankitwanit, Arnon; Swanson, Michael A.; Mitchell, Deborah G.; Eaton, Sandra S.; Eaton, Gareth R.; Rajca, Suchada.

In: Journal of the American Chemical Society, Vol. 134, No. 38, 26.09.2012, p. 15724-15727.

Research output: Contribution to journalArticle

Rajca, A, Wang, Y, Boska, M, Paletta, JT, Olankitwanit, A, Swanson, MA, Mitchell, DG, Eaton, SS, Eaton, GR & Rajca, S 2012, 'Organic radical contrast agents for magnetic resonance imaging', Journal of the American Chemical Society, vol. 134, no. 38, pp. 15724-15727. https://doi.org/10.1021/ja3079829
Rajca A, Wang Y, Boska M, Paletta JT, Olankitwanit A, Swanson MA et al. Organic radical contrast agents for magnetic resonance imaging. Journal of the American Chemical Society. 2012 Sep 26;134(38):15724-15727. https://doi.org/10.1021/ja3079829
Rajca, Andrzej ; Wang, Ying ; Boska, Michael ; Paletta, Joseph T. ; Olankitwanit, Arnon ; Swanson, Michael A. ; Mitchell, Deborah G. ; Eaton, Sandra S. ; Eaton, Gareth R. ; Rajca, Suchada. / Organic radical contrast agents for magnetic resonance imaging. In: Journal of the American Chemical Society. 2012 ; Vol. 134, No. 38. pp. 15724-15727.
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