Organic phosphorus compounds - Nerve agents

Claudia L. Barthold, Joshua G. Schier

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Nerve agents and OPP exposures must be recognized early and treated aggressively. Early airway and ventilatory support should occur in conjunction with antidotal therapy. Atropine should be titrated to control bronchorrhea. Initial pralidoxime therapy should be given as soon as possible in suspected OPC poisoning and ideally before aging occurs. Successful therapy for OPC poisoning may include repeat dosing of pralidoxime or a continuous infusion, depending on the situation. Diazepam should be given to control seizures that may occur in severe poisoning. Late complications depend on the type of OPC involved, and can include intermediate syndrome and peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)673-689
Number of pages17
JournalCritical Care Clinics
Volume21
Issue number4
DOIs
StatePublished - Oct 2005

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Phosphorus Compounds
Poisoning
Peripheral Nervous System Diseases
Diazepam
Atropine
Seizures
Therapeutics
Nerve Agents
pralidoxime

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Organic phosphorus compounds - Nerve agents. / Barthold, Claudia L.; Schier, Joshua G.

In: Critical Care Clinics, Vol. 21, No. 4, 10.2005, p. 673-689.

Research output: Contribution to journalReview article

Barthold, Claudia L. ; Schier, Joshua G. / Organic phosphorus compounds - Nerve agents. In: Critical Care Clinics. 2005 ; Vol. 21, No. 4. pp. 673-689.
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