Abstract
Self-assembled fluorescent nanomaterials based on small-molecule organic dyes are gaining increasing popularity in imaging and sensing applications over the past decade. This is primarily due to their ability to combine spectral properties tunability and biocompatibility of small molecule organic fluorophores with brightness, chemical and colloidal stability of inorganic materials. Such a unique combination of features comes with rich versatility of dye-based nanomaterials: from aggregates of small molecules to sophisticated core-shell nanoarchitectures involving hyperbranched polymers. Along with the ongoing discovery of new materials and better ways of their synthesis, it is very important to continue systematic studies of fundamental factors that regulate the key properties of fluorescent nanomaterials: their size, polydispersity, colloidal stability, chemical stability, absorption and emission maxima, biocompatibility, and interactions with biological interfaces. In this review, we focus on the systematic description of various types of organic fluorescent nanomaterials, approaches to their synthesis, and ways to optimize and control their characteristics. The discussion is built on examples from reports on recent advances in the design and applications of such materials. Conclusions made from this analysis allow a perspective on future development of fluorescent nanomaterials design for biomedical and related applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4042-4064 |
| Number of pages | 23 |
| Journal | Current medicinal chemistry |
| Volume | 26 |
| Issue number | 21 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Organic fluorophores
- colloidal stability
- molecular design
- nanomaterial synthesis
- polymeric aggregates
- spectral properties
- structure-property relationship
- supramolecular assembly.
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Organic Chemistry
Cite this
Organic Fluorescent Dye-based Nanomaterials : Advances in the Rational Design for Imaging and Sensing Applications. / Svechkarev, Denis; Mohs, Aaron M.
In: Current medicinal chemistry, Vol. 26, No. 21, 01.01.2019, p. 4042-4064.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Organic Fluorescent Dye-based Nanomaterials
T2 - Advances in the Rational Design for Imaging and Sensing Applications
AU - Svechkarev, Denis
AU - Mohs, Aaron M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Self-assembled fluorescent nanomaterials based on small-molecule organic dyes are gaining increasing popularity in imaging and sensing applications over the past decade. This is primarily due to their ability to combine spectral properties tunability and biocompatibility of small molecule organic fluorophores with brightness, chemical and colloidal stability of inorganic materials. Such a unique combination of features comes with rich versatility of dye-based nanomaterials: from aggregates of small molecules to sophisticated core-shell nanoarchitectures involving hyperbranched polymers. Along with the ongoing discovery of new materials and better ways of their synthesis, it is very important to continue systematic studies of fundamental factors that regulate the key properties of fluorescent nanomaterials: their size, polydispersity, colloidal stability, chemical stability, absorption and emission maxima, biocompatibility, and interactions with biological interfaces. In this review, we focus on the systematic description of various types of organic fluorescent nanomaterials, approaches to their synthesis, and ways to optimize and control their characteristics. The discussion is built on examples from reports on recent advances in the design and applications of such materials. Conclusions made from this analysis allow a perspective on future development of fluorescent nanomaterials design for biomedical and related applications.
AB - Self-assembled fluorescent nanomaterials based on small-molecule organic dyes are gaining increasing popularity in imaging and sensing applications over the past decade. This is primarily due to their ability to combine spectral properties tunability and biocompatibility of small molecule organic fluorophores with brightness, chemical and colloidal stability of inorganic materials. Such a unique combination of features comes with rich versatility of dye-based nanomaterials: from aggregates of small molecules to sophisticated core-shell nanoarchitectures involving hyperbranched polymers. Along with the ongoing discovery of new materials and better ways of their synthesis, it is very important to continue systematic studies of fundamental factors that regulate the key properties of fluorescent nanomaterials: their size, polydispersity, colloidal stability, chemical stability, absorption and emission maxima, biocompatibility, and interactions with biological interfaces. In this review, we focus on the systematic description of various types of organic fluorescent nanomaterials, approaches to their synthesis, and ways to optimize and control their characteristics. The discussion is built on examples from reports on recent advances in the design and applications of such materials. Conclusions made from this analysis allow a perspective on future development of fluorescent nanomaterials design for biomedical and related applications.
KW - Organic fluorophores
KW - colloidal stability
KW - molecular design
KW - nanomaterial synthesis
KW - polymeric aggregates
KW - spectral properties
KW - structure-property relationship
KW - supramolecular assembly.
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UR - http://www.scopus.com/inward/citedby.url?scp=85072944989&partnerID=8YFLogxK
U2 - 10.2174/0929867325666180226111716
DO - 10.2174/0929867325666180226111716
M3 - Review article
C2 - 29484973
AN - SCOPUS:85072944989
VL - 26
SP - 4042
EP - 4064
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 21
ER -