Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy

Gang Chen, Kaikai Wang, Yiwen Zhou, Ling Ding, Aftab Ullah, Qi Hu, Minjie Sun, David Oupicky

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Photothermal therapy exerts its anticancer effect by converting laser radiation energy into hyperthermia using a suitable photosensitizer. This study reports development of nanostructured lipid carriers (NLCs) suitable for noninvasive oral delivery of a near-infrared photosensitizer dye IR780. The carrier encapsulating the dye (IR780@NLCs) was stable in simulated gastric and intestinal conditions and showed greatly enhanced oral absorption of IR780 when compared with the free dye. As a result of increased oral bioavailability, enhanced accumulation of the dye in subcutaneous mouse colon tumors (CT-26 cells) was observed following oral gavage of IR780@NLCs. Photothermal antitumor activity of orally administered IR780@NLCs was evaluated following local laser irradiation of the CT-26 tumors. We observed significant effect of the photothermal IR780@NLCs treatment on the rate of the tumor growth and no toxicity associated with the oral administration of IR780@NLCs. Overall, orally administered IR780@NLCs represents a safe and noninvasive method to achieve systemic tumor delivery of a photosensitizing dye for applications in photothermal anticancer therapies.

Original languageEnglish (US)
Pages (from-to)25087-25095
Number of pages9
JournalACS Applied Materials and Interfaces
Volume8
Issue number38
DOIs
StatePublished - Sep 28 2016

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Lipids
Coloring Agents
Dyes
Infrared radiation
Tumors
Photosensitizing Agents
Photosensitizers
Laser beam effects
Laser radiation
Toxicity

Keywords

  • IR780
  • nanostructured lipid carriers
  • oral administration
  • photothermal therapy
  • tumor imaging

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy. / Chen, Gang; Wang, Kaikai; Zhou, Yiwen; Ding, Ling; Ullah, Aftab; Hu, Qi; Sun, Minjie; Oupicky, David.

In: ACS Applied Materials and Interfaces, Vol. 8, No. 38, 28.09.2016, p. 25087-25095.

Research output: Contribution to journalArticle

Chen, Gang ; Wang, Kaikai ; Zhou, Yiwen ; Ding, Ling ; Ullah, Aftab ; Hu, Qi ; Sun, Minjie ; Oupicky, David. / Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy. In: ACS Applied Materials and Interfaces. 2016 ; Vol. 8, No. 38. pp. 25087-25095.
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