Oral cavity squamous cell carcinoma and the clinically n0 neck

The past, present, and future of sentinel lymph node biopsy

Andrew M Coughlin, Vicente A. Resto

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Oral cavity squamous cell carcinoma (OCSCC) has a yearly incidence of 274,000 patients. Twenty percent to 30% of patients will harbor occult regional metastases, an important feature that correlates with worse outcomes. Supraomohyoid neck dissection (SND) is the gold standard treatment, but because of recent successes of sentinel lymph node (SLN) biopsy in the management of breast cancer and melanoma, many have begun evaluating its use in head and neck mucosal cancers. SLN biopsy offers patients decreased morbidity compared with SND, and has shown reproducibly low false-negative rates, high-negative predictive values, and high sensitivities. Limitations with floor-of-mouth primaries and delayed secondary SNDs have been described, but a new agent designed to address these shortcomings, Lymphoseek (Neoprobe Corp.; Dublin, OH), is currently under investigation. This article reviews the current literature on SLN biopsy and introduces a phase 3 study evaluating the efficacy of Lymphoseek in SLN biopsy of OCSCCs.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalCurrent Oncology Reports
Volume12
Issue number2
DOIs
StatePublished - Mar 8 2010

Fingerprint

Sentinel Lymph Node Biopsy
Mouth
Squamous Cell Carcinoma
Neck
Neck Dissection
Mouth Floor
Head and Neck Neoplasms
Melanoma
Breast Neoplasms
Neoplasm Metastasis
Morbidity
Incidence
technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran
Therapeutics

Keywords

  • Lymphoscintigraphy
  • Occult lymph node metastases
  • Oral cavity cancer
  • Sentinel lymph node mapping
  • Staging

ASJC Scopus subject areas

  • Oncology

Cite this

Oral cavity squamous cell carcinoma and the clinically n0 neck : The past, present, and future of sentinel lymph node biopsy. / Coughlin, Andrew M; Resto, Vicente A.

In: Current Oncology Reports, Vol. 12, No. 2, 08.03.2010, p. 129-135.

Research output: Contribution to journalReview article

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