Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption

Donald W. Miller, Samuel Augustine, Dennis H. Robinson, Jonathan L. Vennerstrom, Jon C. Wagner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

Original languageEnglish (US)
Title of host publicationNutrition and Enhanced Sports Performance
Subtitle of host publicationMuscle Building, Endurance, and Strength
PublisherElsevier Inc.
Pages395-403
Number of pages9
ISBN (Print)9780123964540
DOIs
Publication statusPublished - Aug 1 2013

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Keywords

  • Creatine bioavailability
  • Creatine ester
  • Creatine salts
  • Oral absorption
  • Paracellular diffusion

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Miller, D. W., Augustine, S., Robinson, D. H., Vennerstrom, J. L., & Wagner, J. C. (2013). Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength (pp. 395-403). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396454-0.00040-0