Typical precast/prestressed concrete sandwich panels (PCSP) consist of an internal wythe of insulation and two external wythes of concrete. They are intended to be structurally composite and thermally efficient. However, frequent penetrations of the insulation wythe with concrete and steel connectors required to achive composite action can significantly diminish the thermal efficiency. NU-PCSP utilizes a patented glass fiber-reinforced polymer (GFRP) connector system (NU-Ties). The system was conceived by researchers at the University of Nebraska-Lincoln in mid 1990s, and has undergone several iterations of refinements since then. The system has been used single family homes, multistory condominiums, and large warehouses. The main advantages of NUTies are high structural performance, low thermal conductivity, and ease of installation. This paper describes the system in detail and provides information on the structural design, thermal analysis and production practice of NU-PCSP. The experimental program to optimize the distribution of NU-Ties and its effect on the flexural capacity and stiffness of PCSP is also presented. Research results indicated that NU-Tie distribution has a significant impact on the flexural capacity and stiffness of PCSPs. Full composite action is attainable and a truss model and finite-element model, rather than a beam model, can better predict panel deformations.