Opposing roles of the Staphylococcus aureus virulence regulators, agr and sar, in triton X-100- and penicillin-induced autolysis

David F. Fujimoto, Kenneth W. Bayles

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The regulation of murein hydrolases is a critical aspect of peptidoglycan growth and metabolism. In the present study, we demonstrate that mutations within the Staphylococcus aureus virulence factor regulatory genes, agr and sar, affect autolysis, resulting in decreased and increased autolysis rates, respectively. Zymographic analyses of these mutant strains suggest that agr and sar exert their effects on autolysis, in part, by modulating murein hydrolase expression and/or activity.

Original languageEnglish (US)
Pages (from-to)3724-3726
Number of pages3
JournalJournal of bacteriology
Volume180
Issue number14
StatePublished - Jul 1 1998

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Autolysis
Octoxynol
N-Acetylmuramoyl-L-alanine Amidase
Penicillins
Virulence
Staphylococcus aureus
Peptidoglycan
Virulence Factors
Regulator Genes
Mutation
Growth

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Opposing roles of the Staphylococcus aureus virulence regulators, agr and sar, in triton X-100- and penicillin-induced autolysis. / Fujimoto, David F.; Bayles, Kenneth W.

In: Journal of bacteriology, Vol. 180, No. 14, 01.07.1998, p. 3724-3726.

Research output: Contribution to journalArticle

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