Abstract

Two main pathways are involved in the carcinogenic activation of polycyclic aromatic hydrocarbons (PAH): one-electron oxidation and monooxygenation. One-electron oxidation produces PAH radical cations, which can react with cellular nucleophiles. Carcinogenicity studies of PAH in rat mammary gland indicate that only PAH with ionization potential low enough for activation by one-electron oxidation induce tumors in this target organ. These results and others indicate that one-electron oxidation of PAH is involved in their tumor initiation process.

Original languageEnglish (US)
Title of host publicationACS Symposium Series
EditorsRonald G. Harvey
PublisherACS
Pages289-305
Number of pages17
ISBN (Print)0841209243
StatePublished - Dec 1 1985

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Cavalieri, E. L., & Rogan, E. G. (1985). ONE-ELECTRON OXIDATION IN AROMATIC HYDROCARBON CARCINOGENESIS. In R. G. Harvey (Ed.), ACS Symposium Series (pp. 289-305). (ACS Symposium Series). ACS.