On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data

Suyeon Kim, Ishwor Thapa, Ling Zhang, Hesham Ali

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The notion of repurposing of existing drugs to treat both common and rare diseases has gained traction from both academia and pharmaceutical companies. Given the high attrition rates, massive time, money, and effort of brand-new drug development, the advantages of drug repurposing in terms of lower costs and shorter development time have become more appealing. Computational drug repurposing is promising approach and has shown great potential in tailoring genomic findings to the development of treatments for diseases. However, there are still challenges involved in building a standard computational drug repurposing solution for high-throughput analysis and the implementation to clinical practice. In this study, we applied the computational drug repurposing approaches for Ulcerative Colitis (UC) patients to provide better treatment for this disabling disease. Repositioning drug candidates were identified, and these findings provide a potentially effective therapeutics for the treatment of UC patients. This preliminary computational drug repurposing pipeline will be extended in the near future to help realize the full potential of drug repurposing.

Original languageEnglish (US)
Title of host publicationBioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings
EditorsOlga Valenzuela, Fernando Rojas, Francisco Ortuño, Francisco Ortuño, Ignacio Rojas
PublisherSpringer Verlag
Pages513-521
Number of pages9
ISBN (Print)9783030179373
DOIs
StatePublished - Jan 1 2019
Event7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019 - Granada, Spain
Duration: May 8 2019May 10 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11465 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019
CountrySpain
CityGranada
Period5/8/195/10/19

Fingerprint

Gene Expression Data
Gene expression
Drugs
Drug products
Pipelines
Throughput
Attrition
Costs
Industry
Pharmaceuticals
High Throughput
Genomics

Keywords

  • Computational tools
  • Drug repurposing
  • Gene expression data
  • Next generation healthcare
  • Systems biology

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Kim, S., Thapa, I., Zhang, L., & Ali, H. (2019). On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data. In O. Valenzuela, F. Rojas, F. Ortuño, F. Ortuño, & I. Rojas (Eds.), Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings (pp. 513-521). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11465 LNBI). Springer Verlag. https://doi.org/10.1007/978-3-030-17938-0_45

On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data. / Kim, Suyeon; Thapa, Ishwor; Zhang, Ling; Ali, Hesham.

Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. ed. / Olga Valenzuela; Fernando Rojas; Francisco Ortuño; Francisco Ortuño; Ignacio Rojas. Springer Verlag, 2019. p. 513-521 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11465 LNBI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, S, Thapa, I, Zhang, L & Ali, H 2019, On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data. in O Valenzuela, F Rojas, F Ortuño, F Ortuño & I Rojas (eds), Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11465 LNBI, Springer Verlag, pp. 513-521, 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, Granada, Spain, 5/8/19. https://doi.org/10.1007/978-3-030-17938-0_45
Kim S, Thapa I, Zhang L, Ali H. On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data. In Valenzuela O, Rojas F, Ortuño F, Ortuño F, Rojas I, editors, Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. Springer Verlag. 2019. p. 513-521. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-030-17938-0_45
Kim, Suyeon ; Thapa, Ishwor ; Zhang, Ling ; Ali, Hesham. / On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data. Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. editor / Olga Valenzuela ; Fernando Rojas ; Francisco Ortuño ; Francisco Ortuño ; Ignacio Rojas. Springer Verlag, 2019. pp. 513-521 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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