Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitopepositive subjects at risk for rheumatoid arthritis

Ryan W. Gan, M. Kristen Demoruelle, Kevin D. Deane, Michael H. Weisman, Jane H. Buckner, Peter K. Gregersen, Ted R Mikuls, James Robert O'Dell, Richard M. Keating, Tasha E. Fingerlin, Gary O. Zerbe, Michael J. Clare-Salzler, V. Michael Holers, Jill M. Norris

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives Previously, we found that omega-3 fatty acids (n-3 FAs) were inversely associated with anti-cyclic citrullinated peptide (anti-CCP) positivity in participants at risk for future rheumatoid arthritis (RA). We investigated whether n-3 FAs were also associated with rheumatoid factor (RF) positivity and whether these associations were modified by shared epitope (SE) positivity. Methods The Studies of the Etiology of RA (SERA) cohort includes RA-free participants who are at increased risk for RA. We conducted a nested case- control study (n=136) to determine the association between RF and anti-CCP2 positivity and n-3 FA percentage in erythrocyte membranes (n-3 FA% in red blood cells (RBCs)). Additionally, in the baseline visit of the SERA cohort (n=2166), we evaluated the association between reported n-3 FA supplement use and prevalence of RF and anti-CCP2. We assessed SE positivity as an effect modifier. Results In the case-control study, increasing n-3 FA% in RBCs was inversely associated with RF positivity in SE-positive participants (OR 0.27, 95% CI 0.10 to 0.79), but not SE-negative participants. Similar associations were seen with anti-CCP positivity in SE-positive participants (OR 0.42, 95% CI 0.20 to 0.89), but not SE-negative participants. In the SERA cohort at baseline, n-3 FA supplement use was associated with a lower prevalence of RF positivity in SE-positive participants (OR 0.32, 95% CI 0.12 to 0.82), but not SE-negative participants; similar but non-significant trends were observed with anti-CCP2. Conclusions The potential protective effect of n-3 FAs on RA-related autoimmunity may be most pronounced in those who exhibit HLA class II genetic susceptibility to RA.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalAnnals of the rheumatic diseases
Volume76
Issue number1
DOIs
StatePublished - Jan 1 2017

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Omega-3 Fatty Acids
Autoantibodies
Epitopes
Rheumatoid Arthritis
Rheumatoid Factor
Case-Control Studies
Blood
Erythrocytes
Erythrocyte Membrane
Genetic Predisposition to Disease
Autoimmunity
Cells
Membranes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitopepositive subjects at risk for rheumatoid arthritis. / Gan, Ryan W.; Demoruelle, M. Kristen; Deane, Kevin D.; Weisman, Michael H.; Buckner, Jane H.; Gregersen, Peter K.; Mikuls, Ted R; O'Dell, James Robert; Keating, Richard M.; Fingerlin, Tasha E.; Zerbe, Gary O.; Clare-Salzler, Michael J.; Holers, V. Michael; Norris, Jill M.

In: Annals of the rheumatic diseases, Vol. 76, No. 1, 01.01.2017, p. 147-152.

Research output: Contribution to journalArticle

Gan, RW, Demoruelle, MK, Deane, KD, Weisman, MH, Buckner, JH, Gregersen, PK, Mikuls, TR, O'Dell, JR, Keating, RM, Fingerlin, TE, Zerbe, GO, Clare-Salzler, MJ, Holers, VM & Norris, JM 2017, 'Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitopepositive subjects at risk for rheumatoid arthritis', Annals of the rheumatic diseases, vol. 76, no. 1, pp. 147-152. https://doi.org/10.1136/annrheumdis-2016-209154
Gan, Ryan W. ; Demoruelle, M. Kristen ; Deane, Kevin D. ; Weisman, Michael H. ; Buckner, Jane H. ; Gregersen, Peter K. ; Mikuls, Ted R ; O'Dell, James Robert ; Keating, Richard M. ; Fingerlin, Tasha E. ; Zerbe, Gary O. ; Clare-Salzler, Michael J. ; Holers, V. Michael ; Norris, Jill M. / Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitopepositive subjects at risk for rheumatoid arthritis. In: Annals of the rheumatic diseases. 2017 ; Vol. 76, No. 1. pp. 147-152.
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title = "Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitopepositive subjects at risk for rheumatoid arthritis",
abstract = "Objectives Previously, we found that omega-3 fatty acids (n-3 FAs) were inversely associated with anti-cyclic citrullinated peptide (anti-CCP) positivity in participants at risk for future rheumatoid arthritis (RA). We investigated whether n-3 FAs were also associated with rheumatoid factor (RF) positivity and whether these associations were modified by shared epitope (SE) positivity. Methods The Studies of the Etiology of RA (SERA) cohort includes RA-free participants who are at increased risk for RA. We conducted a nested case- control study (n=136) to determine the association between RF and anti-CCP2 positivity and n-3 FA percentage in erythrocyte membranes (n-3 FA{\%} in red blood cells (RBCs)). Additionally, in the baseline visit of the SERA cohort (n=2166), we evaluated the association between reported n-3 FA supplement use and prevalence of RF and anti-CCP2. We assessed SE positivity as an effect modifier. Results In the case-control study, increasing n-3 FA{\%} in RBCs was inversely associated with RF positivity in SE-positive participants (OR 0.27, 95{\%} CI 0.10 to 0.79), but not SE-negative participants. Similar associations were seen with anti-CCP positivity in SE-positive participants (OR 0.42, 95{\%} CI 0.20 to 0.89), but not SE-negative participants. In the SERA cohort at baseline, n-3 FA supplement use was associated with a lower prevalence of RF positivity in SE-positive participants (OR 0.32, 95{\%} CI 0.12 to 0.82), but not SE-negative participants; similar but non-significant trends were observed with anti-CCP2. Conclusions The potential protective effect of n-3 FAs on RA-related autoimmunity may be most pronounced in those who exhibit HLA class II genetic susceptibility to RA.",
author = "Gan, {Ryan W.} and Demoruelle, {M. Kristen} and Deane, {Kevin D.} and Weisman, {Michael H.} and Buckner, {Jane H.} and Gregersen, {Peter K.} and Mikuls, {Ted R} and O'Dell, {James Robert} and Keating, {Richard M.} and Fingerlin, {Tasha E.} and Zerbe, {Gary O.} and Clare-Salzler, {Michael J.} and Holers, {V. Michael} and Norris, {Jill M.}",
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T1 - Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitopepositive subjects at risk for rheumatoid arthritis

AU - Gan, Ryan W.

AU - Demoruelle, M. Kristen

AU - Deane, Kevin D.

AU - Weisman, Michael H.

AU - Buckner, Jane H.

AU - Gregersen, Peter K.

AU - Mikuls, Ted R

AU - O'Dell, James Robert

AU - Keating, Richard M.

AU - Fingerlin, Tasha E.

AU - Zerbe, Gary O.

AU - Clare-Salzler, Michael J.

AU - Holers, V. Michael

AU - Norris, Jill M.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives Previously, we found that omega-3 fatty acids (n-3 FAs) were inversely associated with anti-cyclic citrullinated peptide (anti-CCP) positivity in participants at risk for future rheumatoid arthritis (RA). We investigated whether n-3 FAs were also associated with rheumatoid factor (RF) positivity and whether these associations were modified by shared epitope (SE) positivity. Methods The Studies of the Etiology of RA (SERA) cohort includes RA-free participants who are at increased risk for RA. We conducted a nested case- control study (n=136) to determine the association between RF and anti-CCP2 positivity and n-3 FA percentage in erythrocyte membranes (n-3 FA% in red blood cells (RBCs)). Additionally, in the baseline visit of the SERA cohort (n=2166), we evaluated the association between reported n-3 FA supplement use and prevalence of RF and anti-CCP2. We assessed SE positivity as an effect modifier. Results In the case-control study, increasing n-3 FA% in RBCs was inversely associated with RF positivity in SE-positive participants (OR 0.27, 95% CI 0.10 to 0.79), but not SE-negative participants. Similar associations were seen with anti-CCP positivity in SE-positive participants (OR 0.42, 95% CI 0.20 to 0.89), but not SE-negative participants. In the SERA cohort at baseline, n-3 FA supplement use was associated with a lower prevalence of RF positivity in SE-positive participants (OR 0.32, 95% CI 0.12 to 0.82), but not SE-negative participants; similar but non-significant trends were observed with anti-CCP2. Conclusions The potential protective effect of n-3 FAs on RA-related autoimmunity may be most pronounced in those who exhibit HLA class II genetic susceptibility to RA.

AB - Objectives Previously, we found that omega-3 fatty acids (n-3 FAs) were inversely associated with anti-cyclic citrullinated peptide (anti-CCP) positivity in participants at risk for future rheumatoid arthritis (RA). We investigated whether n-3 FAs were also associated with rheumatoid factor (RF) positivity and whether these associations were modified by shared epitope (SE) positivity. Methods The Studies of the Etiology of RA (SERA) cohort includes RA-free participants who are at increased risk for RA. We conducted a nested case- control study (n=136) to determine the association between RF and anti-CCP2 positivity and n-3 FA percentage in erythrocyte membranes (n-3 FA% in red blood cells (RBCs)). Additionally, in the baseline visit of the SERA cohort (n=2166), we evaluated the association between reported n-3 FA supplement use and prevalence of RF and anti-CCP2. We assessed SE positivity as an effect modifier. Results In the case-control study, increasing n-3 FA% in RBCs was inversely associated with RF positivity in SE-positive participants (OR 0.27, 95% CI 0.10 to 0.79), but not SE-negative participants. Similar associations were seen with anti-CCP positivity in SE-positive participants (OR 0.42, 95% CI 0.20 to 0.89), but not SE-negative participants. In the SERA cohort at baseline, n-3 FA supplement use was associated with a lower prevalence of RF positivity in SE-positive participants (OR 0.32, 95% CI 0.12 to 0.82), but not SE-negative participants; similar but non-significant trends were observed with anti-CCP2. Conclusions The potential protective effect of n-3 FAs on RA-related autoimmunity may be most pronounced in those who exhibit HLA class II genetic susceptibility to RA.

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