Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: Associations with disease course and progression

Pedro Lourenco, Afsaneh Shirani, Jameelah Saeedi, Joel Oger, William E. Schreiber, Helen Tremlett

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The use of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) parameters are established in the diagnosis of MS, but poorly as markers of disease. Objective: To investigate the role of OCBs in disease course and progression. Methods: CSF data for 1120 patients with MS were analyzed for associations between OCBs and CSF parameters and clinical data (disease course [relapsing-onset MS (ROMS) vs primary-progressive MS (PPMS)]), disability progression (proportion reaching Expanded Disability Status Scale 6 within 10 years of onset and progression index) and ethnicity. Results: Of patients with MS, 72.5% had detectable OCBs. For patients with detectable OCBs, 84.6% had ROMS and 15.4% PPMS versus 89.7% and 10.3%, respectively for those without detectable OCBs (p=0.04). Total CSF IgG and protein levels were higher in PPMS compared with ROMS (p<0.001). Disease progression appeared independent of OCB status. Patients with CSF (vs without) data were more likely to be male, older at onset, have PPMS and lack optic neuropathy at onset (p<0.001). Conclusions: OCB positivity and elevated total CSF IgG and protein were moderately associated with a PPMS disease course, but not disease progression. Patients with atypical clinical presentations were more likely to have had CSF work-up, suggesting a testing bias.

Original languageEnglish (US)
Pages (from-to)577-584
Number of pages8
JournalMultiple Sclerosis Journal
Volume19
Issue number5
DOIs
StatePublished - Apr 2013

Fingerprint

Oligoclonal Bands
Multiple Sclerosis
Cerebrospinal Fluid
Disease Progression
Cerebrospinal Fluid Proteins
Immunoglobulin G
Optic Nerve Diseases

Keywords

  • CNS
  • cerebrospinal fluid
  • chronic progressive
  • demyelinating autoimmune diseases
  • ethnicity
  • multiple sclerosis
  • natural history studies (prognosis)
  • oligoclonal IgG
  • prognosis
  • relapsing-remitting multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis : Associations with disease course and progression. / Lourenco, Pedro; Shirani, Afsaneh; Saeedi, Jameelah; Oger, Joel; Schreiber, William E.; Tremlett, Helen.

In: Multiple Sclerosis Journal, Vol. 19, No. 5, 04.2013, p. 577-584.

Research output: Contribution to journalArticle

Lourenco, Pedro ; Shirani, Afsaneh ; Saeedi, Jameelah ; Oger, Joel ; Schreiber, William E. ; Tremlett, Helen. / Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis : Associations with disease course and progression. In: Multiple Sclerosis Journal. 2013 ; Vol. 19, No. 5. pp. 577-584.
@article{fc19b5e7715546fcb7d9061aaf03800c,
title = "Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: Associations with disease course and progression",
abstract = "Background: The use of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) parameters are established in the diagnosis of MS, but poorly as markers of disease. Objective: To investigate the role of OCBs in disease course and progression. Methods: CSF data for 1120 patients with MS were analyzed for associations between OCBs and CSF parameters and clinical data (disease course [relapsing-onset MS (ROMS) vs primary-progressive MS (PPMS)]), disability progression (proportion reaching Expanded Disability Status Scale 6 within 10 years of onset and progression index) and ethnicity. Results: Of patients with MS, 72.5{\%} had detectable OCBs. For patients with detectable OCBs, 84.6{\%} had ROMS and 15.4{\%} PPMS versus 89.7{\%} and 10.3{\%}, respectively for those without detectable OCBs (p=0.04). Total CSF IgG and protein levels were higher in PPMS compared with ROMS (p<0.001). Disease progression appeared independent of OCB status. Patients with CSF (vs without) data were more likely to be male, older at onset, have PPMS and lack optic neuropathy at onset (p<0.001). Conclusions: OCB positivity and elevated total CSF IgG and protein were moderately associated with a PPMS disease course, but not disease progression. Patients with atypical clinical presentations were more likely to have had CSF work-up, suggesting a testing bias.",
keywords = "CNS, cerebrospinal fluid, chronic progressive, demyelinating autoimmune diseases, ethnicity, multiple sclerosis, natural history studies (prognosis), oligoclonal IgG, prognosis, relapsing-remitting multiple sclerosis",
author = "Pedro Lourenco and Afsaneh Shirani and Jameelah Saeedi and Joel Oger and Schreiber, {William E.} and Helen Tremlett",
year = "2013",
month = "4",
doi = "10.1177/1352458512459684",
language = "English (US)",
volume = "19",
pages = "577--584",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis

T2 - Associations with disease course and progression

AU - Lourenco, Pedro

AU - Shirani, Afsaneh

AU - Saeedi, Jameelah

AU - Oger, Joel

AU - Schreiber, William E.

AU - Tremlett, Helen

PY - 2013/4

Y1 - 2013/4

N2 - Background: The use of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) parameters are established in the diagnosis of MS, but poorly as markers of disease. Objective: To investigate the role of OCBs in disease course and progression. Methods: CSF data for 1120 patients with MS were analyzed for associations between OCBs and CSF parameters and clinical data (disease course [relapsing-onset MS (ROMS) vs primary-progressive MS (PPMS)]), disability progression (proportion reaching Expanded Disability Status Scale 6 within 10 years of onset and progression index) and ethnicity. Results: Of patients with MS, 72.5% had detectable OCBs. For patients with detectable OCBs, 84.6% had ROMS and 15.4% PPMS versus 89.7% and 10.3%, respectively for those without detectable OCBs (p=0.04). Total CSF IgG and protein levels were higher in PPMS compared with ROMS (p<0.001). Disease progression appeared independent of OCB status. Patients with CSF (vs without) data were more likely to be male, older at onset, have PPMS and lack optic neuropathy at onset (p<0.001). Conclusions: OCB positivity and elevated total CSF IgG and protein were moderately associated with a PPMS disease course, but not disease progression. Patients with atypical clinical presentations were more likely to have had CSF work-up, suggesting a testing bias.

AB - Background: The use of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) parameters are established in the diagnosis of MS, but poorly as markers of disease. Objective: To investigate the role of OCBs in disease course and progression. Methods: CSF data for 1120 patients with MS were analyzed for associations between OCBs and CSF parameters and clinical data (disease course [relapsing-onset MS (ROMS) vs primary-progressive MS (PPMS)]), disability progression (proportion reaching Expanded Disability Status Scale 6 within 10 years of onset and progression index) and ethnicity. Results: Of patients with MS, 72.5% had detectable OCBs. For patients with detectable OCBs, 84.6% had ROMS and 15.4% PPMS versus 89.7% and 10.3%, respectively for those without detectable OCBs (p=0.04). Total CSF IgG and protein levels were higher in PPMS compared with ROMS (p<0.001). Disease progression appeared independent of OCB status. Patients with CSF (vs without) data were more likely to be male, older at onset, have PPMS and lack optic neuropathy at onset (p<0.001). Conclusions: OCB positivity and elevated total CSF IgG and protein were moderately associated with a PPMS disease course, but not disease progression. Patients with atypical clinical presentations were more likely to have had CSF work-up, suggesting a testing bias.

KW - CNS

KW - cerebrospinal fluid

KW - chronic progressive

KW - demyelinating autoimmune diseases

KW - ethnicity

KW - multiple sclerosis

KW - natural history studies (prognosis)

KW - oligoclonal IgG

KW - prognosis

KW - relapsing-remitting multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=84876517388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876517388&partnerID=8YFLogxK

U2 - 10.1177/1352458512459684

DO - 10.1177/1352458512459684

M3 - Article

C2 - 22961214

AN - SCOPUS:84876517388

VL - 19

SP - 577

EP - 584

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 5

ER -