Ocular drug delivery

Deepta Ghate, Henry F. Edelhauser

Research output: Contribution to journalReview article

173 Citations (Scopus)

Abstract

Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these drug delivery routes have been emphasised. Recent advances in surgical techniques, therapeutic approaches and material sciences have produced exciting new therapies for ocular diseases. The role of ophthalmic drug formulation in targeting the desired ocular tissue and enhancing drug delivery by the chosen route whilst minimising side effects is also discussed.

Original languageEnglish (US)
Pages (from-to)275-287
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume3
Issue number2
DOIs
StatePublished - Mar 1 2006

Fingerprint

Pharmaceutical Preparations
Blood-Aqueous Barrier
Blood-Retinal Barrier
Drug Compounding
Corneal Epithelium
Eye Diseases
Pharmacokinetics
Therapeutics

Keywords

  • Intravitreal injection
  • Ocular drug delivery
  • Ocular pharmacokinetics
  • Posterior subtenon injection
  • Topical drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Ocular drug delivery. / Ghate, Deepta; Edelhauser, Henry F.

In: Expert Opinion on Drug Delivery, Vol. 3, No. 2, 01.03.2006, p. 275-287.

Research output: Contribution to journalReview article

Ghate, Deepta ; Edelhauser, Henry F. / Ocular drug delivery. In: Expert Opinion on Drug Delivery. 2006 ; Vol. 3, No. 2. pp. 275-287.
@article{5f16c8fe2bb5442a815ff5b8b905b24a,
title = "Ocular drug delivery",
abstract = "Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these drug delivery routes have been emphasised. Recent advances in surgical techniques, therapeutic approaches and material sciences have produced exciting new therapies for ocular diseases. The role of ophthalmic drug formulation in targeting the desired ocular tissue and enhancing drug delivery by the chosen route whilst minimising side effects is also discussed.",
keywords = "Intravitreal injection, Ocular drug delivery, Ocular pharmacokinetics, Posterior subtenon injection, Topical drug delivery",
author = "Deepta Ghate and Edelhauser, {Henry F.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1517/17425247.3.2.275",
language = "English (US)",
volume = "3",
pages = "275--287",
journal = "Expert Opinion on Drug Delivery",
issn = "1742-5247",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Ocular drug delivery

AU - Ghate, Deepta

AU - Edelhauser, Henry F.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these drug delivery routes have been emphasised. Recent advances in surgical techniques, therapeutic approaches and material sciences have produced exciting new therapies for ocular diseases. The role of ophthalmic drug formulation in targeting the desired ocular tissue and enhancing drug delivery by the chosen route whilst minimising side effects is also discussed.

AB - Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these drug delivery routes have been emphasised. Recent advances in surgical techniques, therapeutic approaches and material sciences have produced exciting new therapies for ocular diseases. The role of ophthalmic drug formulation in targeting the desired ocular tissue and enhancing drug delivery by the chosen route whilst minimising side effects is also discussed.

KW - Intravitreal injection

KW - Ocular drug delivery

KW - Ocular pharmacokinetics

KW - Posterior subtenon injection

KW - Topical drug delivery

UR - http://www.scopus.com/inward/record.url?scp=33644778489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644778489&partnerID=8YFLogxK

U2 - 10.1517/17425247.3.2.275

DO - 10.1517/17425247.3.2.275

M3 - Review article

C2 - 16506953

AN - SCOPUS:33644778489

VL - 3

SP - 275

EP - 287

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

IS - 2

ER -