Octreotide acetate attenuates bombesin induced gastroprotection

D. W. Mercer, L. Chang, L. M. Lichtenberger

Research output: Contribution to journalArticle

Abstract

Bombesin prevents gastric injury from acidified ethanol, an effect negated by gastrin receptor blockade. This study was done in conscious female rats (N ≥ 5/group) to ascertain what effect bombesin has on gastrin secretion and determine whether this action and/or bombesin-induced gastroprotection is diminished by the antisecretory agent octreotide acetate, a somatostatin analogue. As shown below, bombesin (60 nmol/kg sc) reduced macroscopic injury to the stomach caused by 1 ml of orogastric acidified ethanol (150 mM HCl/50% ethanol) and increased serum gastrin levels (radiounmunoassay). Administration of octreotide acetate (1 nmol/kg sc) partially reversed both effects of bombesin. Data are mean ±SEM. 30 Minute Pretreatments Gastric Injury (mm2) Serum Gastrin (fmol/ml) Significance (ANOVA) Saline/Saline 109 ± 9 110 ± 10*p < 0.001 vs. Saline/Bombesin 7 ± 2*539 ± 31*Saline/Saline Octreotide/Saline 111 ± 11 103 ± 12**p = 0.001 vs. Octreotide/Bombesin 41 ± 4**271 ± 28**Saline/Bombesin This study indicates that both the gastroprotective actions and release of endogenous gastrin by bombesin are mediated, in part, by a somatostatin sensitive mechanism.

Original languageEnglish (US)
Pages (from-to)A219
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

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ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Mercer, D. W., Chang, L., & Lichtenberger, L. M. (1997). Octreotide acetate attenuates bombesin induced gastroprotection. FASEB Journal, 11(3), A219.