Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Lai Ching Lau, Ping Lim, Yik Chen Lim, Li Min Teng, Tse Hui Lim, Lay Cheng Lim, Soo Yong Tan, Soon Tiong Lim, Warren G Sanger, Sim Leng Tien

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume185
Issue number2
DOIs
StatePublished - Sep 1 2008

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Trisomy
B-Cell Chronic Lymphocytic Leukemia
Follicular Lymphoma
Chromosome Aberrations
T-Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia. / Lau, Lai Ching; Lim, Ping; Lim, Yik Chen; Teng, Li Min; Lim, Tse Hui; Lim, Lay Cheng; Tan, Soo Yong; Lim, Soon Tiong; Sanger, Warren G; Tien, Sim Leng.

In: Cancer Genetics and Cytogenetics, Vol. 185, No. 2, 01.09.2008, p. 95-101.

Research output: Contribution to journalArticle

Lau, Lai Ching ; Lim, Ping ; Lim, Yik Chen ; Teng, Li Min ; Lim, Tse Hui ; Lim, Lay Cheng ; Tan, Soo Yong ; Lim, Soon Tiong ; Sanger, Warren G ; Tien, Sim Leng. / Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia. In: Cancer Genetics and Cytogenetics. 2008 ; Vol. 185, No. 2. pp. 95-101.
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abstract = "Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.",
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AU - Teng, Li Min

AU - Lim, Tse Hui

AU - Lim, Lay Cheng

AU - Tan, Soo Yong

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